Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.

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Detalles Bibliográficos
Autores principales: Jeffrey P. North, Justin Golovato, Charles J. Vaske, J. Zachary Sanborn, Andrew Nguyen, Wei Wu, Benjamin Goode, Meredith Stevers, Kevin McMullen, Bethany E. Perez White, Eric A. Collisson, Michele Bloomer, David A. Solomon, Stephen C. Benz, Raymond J. Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a7a23b1126f944b2aad81a9029010a17
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Descripción
Sumario:Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.

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