Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.

Guardado en:
Detalles Bibliográficos
Autores principales: Jeffrey P. North, Justin Golovato, Charles J. Vaske, J. Zachary Sanborn, Andrew Nguyen, Wei Wu, Benjamin Goode, Meredith Stevers, Kevin McMullen, Bethany E. Perez White, Eric A. Collisson, Michele Bloomer, David A. Solomon, Stephen C. Benz, Raymond J. Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/a7a23b1126f944b2aad81a9029010a17
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a7a23b1126f944b2aad81a9029010a17
record_format dspace
spelling oai:doaj.org-article:a7a23b1126f944b2aad81a9029010a172021-12-02T16:50:10ZCell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma10.1038/s41467-018-04008-y2041-1723https://doaj.org/article/a7a23b1126f944b2aad81a9029010a172018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04008-yhttps://doaj.org/toc/2041-1723Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.Jeffrey P. NorthJustin GolovatoCharles J. VaskeJ. Zachary SanbornAndrew NguyenWei WuBenjamin GoodeMeredith SteversKevin McMullenBethany E. Perez WhiteEric A. CollissonMichele BloomerDavid A. SolomonStephen C. BenzRaymond J. ChoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jeffrey P. North
Justin Golovato
Charles J. Vaske
J. Zachary Sanborn
Andrew Nguyen
Wei Wu
Benjamin Goode
Meredith Stevers
Kevin McMullen
Bethany E. Perez White
Eric A. Collisson
Michele Bloomer
David A. Solomon
Stephen C. Benz
Raymond J. Cho
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
description Sebaceous carcinomas (SeC) are cutaneous malignancies that sometimes metastasize and cause death. Here the authors perform whole-exome sequencing on 32 SeC and report distinct mutational classes that may explain cancer ontogeny and clinical outcome.
format article
author Jeffrey P. North
Justin Golovato
Charles J. Vaske
J. Zachary Sanborn
Andrew Nguyen
Wei Wu
Benjamin Goode
Meredith Stevers
Kevin McMullen
Bethany E. Perez White
Eric A. Collisson
Michele Bloomer
David A. Solomon
Stephen C. Benz
Raymond J. Cho
author_facet Jeffrey P. North
Justin Golovato
Charles J. Vaske
J. Zachary Sanborn
Andrew Nguyen
Wei Wu
Benjamin Goode
Meredith Stevers
Kevin McMullen
Bethany E. Perez White
Eric A. Collisson
Michele Bloomer
David A. Solomon
Stephen C. Benz
Raymond J. Cho
author_sort Jeffrey P. North
title Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
title_short Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
title_full Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
title_fullStr Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
title_full_unstemmed Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
title_sort cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a7a23b1126f944b2aad81a9029010a17
work_keys_str_mv AT jeffreypnorth celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT justingolovato celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT charlesjvaske celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT jzacharysanborn celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT andrewnguyen celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT weiwu celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT benjamingoode celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT meredithstevers celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT kevinmcmullen celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT bethanyeperezwhite celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT ericacollisson celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT michelebloomer celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT davidasolomon celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT stephencbenz celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
AT raymondjcho celloforiginandmutationpatterndefinethreeclinicallydistinctclassesofsebaceouscarcinoma
_version_ 1718383117889175552