Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series

Abstract Background Umbilical artery thrombosis is a rare complication of pregnancy strongly associated with poor fetal and perinatal outcomes, such as intrauterine asphyxia, fetal growth restriction, and stillbirth. Its pathogenesis remains unclear, and there is the added challenge of selecting an...

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Autores principales:	Jing Wei, Qiaoyun Li, Hongbo Zhai
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pregnancy Umbilical artery thrombosis Umbilical cord thrombosis Umbilical cord abnormality Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/a7a499a0860a46f79bb12d8147058ff8
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spelling	oai:doaj.org-article:a7a499a0860a46f79bb12d8147058ff82021-11-28T12:29:43ZUmbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series10.1186/s12884-021-04264-91471-2393https://doaj.org/article/a7a499a0860a46f79bb12d8147058ff82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04264-9https://doaj.org/toc/1471-2393Abstract Background Umbilical artery thrombosis is a rare complication of pregnancy strongly associated with poor fetal and perinatal outcomes, such as intrauterine asphyxia, fetal growth restriction, and stillbirth. Its pathogenesis remains unclear, and there is the added challenge of selecting an appropriate delivery time to achieve excellent neonatal outcomes. Methods Our Hospital is a critical maternal rescue center with approximately 7000 births annually. We present a series of 8 cases of umbilical artery thrombosis diagnosed at the hospital between Apr 1, 2018, and Jan 31, 2020. We identified the cases through a keyword search of the maternity and pathology information management systems. Results Three patients were diagnosed with a transabdominal ultrasound scan and hypoxia on fetal heart monitoring. All three patients had emergency cesarean section delivery. Four patients were observed closely for 5 to 13 weeks from initial detection by an ultrasound scan to delivery. Only one patient was diagnosed after vaginal delivery by Hematoxylin-eosin staining of umbilical cord sections. Seven patients had deliveries by cesarean section, and one patient had a vaginal delivery. All infants were born alive. Conclusions Umbilical artery thrombosis is a challenging and rare condition that can occur at different gestational ages, especially when diagnosed in the third trimester and accompanied by fetal growth restriction. Consequently, these patients require close monitoring of umbilical blood flow and fetal growth and intervention at the appropriate time to achieve an optimal outcome.Jing WeiQiaoyun LiHongbo ZhaiBMCarticlePregnancyUmbilical artery thrombosisUmbilical cord thrombosisUmbilical cord abnormalityGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pregnancy Umbilical artery thrombosis Umbilical cord thrombosis Umbilical cord abnormality Gynecology and obstetrics RG1-991
spellingShingle	Pregnancy Umbilical artery thrombosis Umbilical cord thrombosis Umbilical cord abnormality Gynecology and obstetrics RG1-991 Jing Wei Qiaoyun Li Hongbo Zhai Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
description	Abstract Background Umbilical artery thrombosis is a rare complication of pregnancy strongly associated with poor fetal and perinatal outcomes, such as intrauterine asphyxia, fetal growth restriction, and stillbirth. Its pathogenesis remains unclear, and there is the added challenge of selecting an appropriate delivery time to achieve excellent neonatal outcomes. Methods Our Hospital is a critical maternal rescue center with approximately 7000 births annually. We present a series of 8 cases of umbilical artery thrombosis diagnosed at the hospital between Apr 1, 2018, and Jan 31, 2020. We identified the cases through a keyword search of the maternity and pathology information management systems. Results Three patients were diagnosed with a transabdominal ultrasound scan and hypoxia on fetal heart monitoring. All three patients had emergency cesarean section delivery. Four patients were observed closely for 5 to 13 weeks from initial detection by an ultrasound scan to delivery. Only one patient was diagnosed after vaginal delivery by Hematoxylin-eosin staining of umbilical cord sections. Seven patients had deliveries by cesarean section, and one patient had a vaginal delivery. All infants were born alive. Conclusions Umbilical artery thrombosis is a challenging and rare condition that can occur at different gestational ages, especially when diagnosed in the third trimester and accompanied by fetal growth restriction. Consequently, these patients require close monitoring of umbilical blood flow and fetal growth and intervention at the appropriate time to achieve an optimal outcome.
format	article
author	Jing Wei Qiaoyun Li Hongbo Zhai
author_facet	Jing Wei Qiaoyun Li Hongbo Zhai
author_sort	Jing Wei
title	Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
title_short	Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
title_full	Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
title_fullStr	Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
title_full_unstemmed	Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
title_sort	umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a7a499a0860a46f79bb12d8147058ff8
work_keys_str_mv	AT jingwei umbilicalarterythrombosisdiagnosedatdifferentgestationalagesandfetaloutcomesacaseseries AT qiaoyunli umbilicalarterythrombosisdiagnosedatdifferentgestationalagesandfetaloutcomesacaseseries AT hongbozhai umbilicalarterythrombosisdiagnosedatdifferentgestationalagesandfetaloutcomesacaseseries
_version_	1718407974575144960

Umbilical artery thrombosis diagnosed at different gestational ages and fetal outcomes: a case series

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