Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment

Abstract Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies to restore the efficacy of insecticides. Although we have substantially impr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Henry F. Owusu, Nakul Chitnis, Pie Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7a890ee41ee46c5bbd0502ac322c99b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a7a890ee41ee46c5bbd0502ac322c99b
record_format	dspace
spelling	oai:doaj.org-article:a7a890ee41ee46c5bbd0502ac322c99b2021-12-02T12:31:46ZInsecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment10.1038/s41598-017-03918-z2045-2322https://doaj.org/article/a7a890ee41ee46c5bbd0502ac322c99b2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03918-zhttps://doaj.org/toc/2045-2322Abstract Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies to restore the efficacy of insecticides. Although we have substantially improved our understanding of the genetic basis of insecticide resistance over the last decade, we still know little of how environmental variations influence the mosquito phenotype. Here, we measured how variations in larval rearing conditions change the insecticide susceptibility phenotype of adult Anopheles mosquitoes. Anopheles gambiae and A. stephensi larvae were bred under different combinations of temperature, population density and nutrition, and the emerging adults were exposed to permethrin. Mosquitoes bred under different conditions showed considerable changes in mortality rates and body weight, with nutrition being the major factor. Weight is a strong predictor of insecticide susceptibility and bigger mosquitoes are more likely to survive insecticide treatment. The changes can be substantial, such that the same mosquito colony may be considered fully susceptible or highly resistant when judged by World Health Organization discriminatory concentrations. The results shown here emphasise the importance of the environmental background in developing insecticide resistance phenotypes, and caution for the interpretation of data generated by insecticide susceptibility assays.Henry F. OwusuNakul ChitnisPie MüllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henry F. Owusu Nakul Chitnis Pie Müller Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
description	Abstract Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies to restore the efficacy of insecticides. Although we have substantially improved our understanding of the genetic basis of insecticide resistance over the last decade, we still know little of how environmental variations influence the mosquito phenotype. Here, we measured how variations in larval rearing conditions change the insecticide susceptibility phenotype of adult Anopheles mosquitoes. Anopheles gambiae and A. stephensi larvae were bred under different combinations of temperature, population density and nutrition, and the emerging adults were exposed to permethrin. Mosquitoes bred under different conditions showed considerable changes in mortality rates and body weight, with nutrition being the major factor. Weight is a strong predictor of insecticide susceptibility and bigger mosquitoes are more likely to survive insecticide treatment. The changes can be substantial, such that the same mosquito colony may be considered fully susceptible or highly resistant when judged by World Health Organization discriminatory concentrations. The results shown here emphasise the importance of the environmental background in developing insecticide resistance phenotypes, and caution for the interpretation of data generated by insecticide susceptibility assays.
format	article
author	Henry F. Owusu Nakul Chitnis Pie Müller
author_facet	Henry F. Owusu Nakul Chitnis Pie Müller
author_sort	Henry F. Owusu
title	Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
title_short	Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
title_full	Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
title_fullStr	Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
title_full_unstemmed	Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment
title_sort	insecticide susceptibility of anopheles mosquitoes changes in response to variations in the larval environment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a7a890ee41ee46c5bbd0502ac322c99b
work_keys_str_mv	AT henryfowusu insecticidesusceptibilityofanophelesmosquitoeschangesinresponsetovariationsinthelarvalenvironment AT nakulchitnis insecticidesusceptibilityofanophelesmosquitoeschangesinresponsetovariationsinthelarvalenvironment AT piemuller insecticidesusceptibilityofanophelesmosquitoeschangesinresponsetovariationsinthelarvalenvironment
_version_	1718394298062340096

Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment

Ejemplares similares