Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models

Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3...

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Autores principales:	Garcia-Lazaro Rocio Soledad, Caligiuri Lorena Gisel, Lorenzo Norailys, Lamdan Humberto, Alonso Daniel Fernando, Farina Hernan Gabriel
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast cancer Yerba mate polyphenols tumor progression metastasis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a7ac6fdea3374455a3103b2cd23ca7f2
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spelling	oai:doaj.org-article:a7ac6fdea3374455a3103b2cd23ca7f22021-11-11T08:00:48ZYerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models1663-981210.3389/fphar.2021.750197https://doaj.org/article/a7ac6fdea3374455a3103b2cd23ca7f22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.750197/fullhttps://doaj.org/toc/1663-9812Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.Garcia-Lazaro Rocio SoledadCaligiuri Lorena GiselLorenzo NorailysLamdan HumbertoAlonso Daniel FernandoFarina Hernan GabrielFrontiers Media S.A.articlebreast cancerYerba matepolyphenolstumor progressionmetastasisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer Yerba mate polyphenols tumor progression metastasis Therapeutics. Pharmacology RM1-950
spellingShingle	breast cancer Yerba mate polyphenols tumor progression metastasis Therapeutics. Pharmacology RM1-950 Garcia-Lazaro Rocio Soledad Caligiuri Lorena Gisel Lorenzo Norailys Lamdan Humberto Alonso Daniel Fernando Farina Hernan Gabriel Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
description	Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.
format	article
author	Garcia-Lazaro Rocio Soledad Caligiuri Lorena Gisel Lorenzo Norailys Lamdan Humberto Alonso Daniel Fernando Farina Hernan Gabriel
author_facet	Garcia-Lazaro Rocio Soledad Caligiuri Lorena Gisel Lorenzo Norailys Lamdan Humberto Alonso Daniel Fernando Farina Hernan Gabriel
author_sort	Garcia-Lazaro Rocio Soledad
title	Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_short	Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_full	Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_fullStr	Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_full_unstemmed	Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_sort	yerba mate modulates tumor cells functions involved in metastasis in breast cancer models
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a7ac6fdea3374455a3103b2cd23ca7f2
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Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models

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