Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms
Obesity is a highly prevalent public health concern, attributed to multifactorial causes and limited in treatment options. Several comorbidities are closely associated with obesity such as the development of type 2 diabetes mellitus (T2DM), cardiovascular and cerebrovascular diseases, and nonalcohol...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a7b058943d674ca19f9bd519277487e9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a7b058943d674ca19f9bd519277487e9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a7b058943d674ca19f9bd519277487e92021-11-25T16:52:15ZEffect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms10.3390/biom111115822218-273Xhttps://doaj.org/article/a7b058943d674ca19f9bd519277487e92021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1582https://doaj.org/toc/2218-273XObesity is a highly prevalent public health concern, attributed to multifactorial causes and limited in treatment options. Several comorbidities are closely associated with obesity such as the development of type 2 diabetes mellitus (T2DM), cardiovascular and cerebrovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Bariatric surgery, which can be delivered in multiple forms, has been remarked as an effective treatment to decrease the prevalence of obesity and its associated comorbidities. The different types of bariatric surgery create a variety of new pathways for food to metabolize in the body and truncate the stomach’s caliber. As a result, only a small quantity of food is tolerated, and the body mass index noticeably decreases. This review describes the improvements of obesity and its comorbidities following bariatric surgery and their mechanism of improvement. Additionally, endocrine function improvements after bariatric surgery, which contributes to the patients’ health improvement, are described, including the role of glucagon-like peptide-1 (GLP-1), fibroblast growth factors 19 and 21 (FGF-19, FGF-21), and pancreatic peptide YY (PYY). Lastly, some of the complications of bariatric surgery, including osteoporosis, iron deficiency/anemia, and diarrhea, as well as their potential mechanisms, are described.Yu JiHangil LeeShawn KauraJames YipHao SunLongfei GuanWei HanYuchuan DingMDPI AGarticleobesitymetabolic disorderscomplicationsmechanismscardiovascular diseasesMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1582, p 1582 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
obesity metabolic disorders complications mechanisms cardiovascular diseases Microbiology QR1-502 |
| spellingShingle |
obesity metabolic disorders complications mechanisms cardiovascular diseases Microbiology QR1-502 Yu Ji Hangil Lee Shawn Kaura James Yip Hao Sun Longfei Guan Wei Han Yuchuan Ding Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| description |
Obesity is a highly prevalent public health concern, attributed to multifactorial causes and limited in treatment options. Several comorbidities are closely associated with obesity such as the development of type 2 diabetes mellitus (T2DM), cardiovascular and cerebrovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Bariatric surgery, which can be delivered in multiple forms, has been remarked as an effective treatment to decrease the prevalence of obesity and its associated comorbidities. The different types of bariatric surgery create a variety of new pathways for food to metabolize in the body and truncate the stomach’s caliber. As a result, only a small quantity of food is tolerated, and the body mass index noticeably decreases. This review describes the improvements of obesity and its comorbidities following bariatric surgery and their mechanism of improvement. Additionally, endocrine function improvements after bariatric surgery, which contributes to the patients’ health improvement, are described, including the role of glucagon-like peptide-1 (GLP-1), fibroblast growth factors 19 and 21 (FGF-19, FGF-21), and pancreatic peptide YY (PYY). Lastly, some of the complications of bariatric surgery, including osteoporosis, iron deficiency/anemia, and diarrhea, as well as their potential mechanisms, are described. |
| format |
article |
| author |
Yu Ji Hangil Lee Shawn Kaura James Yip Hao Sun Longfei Guan Wei Han Yuchuan Ding |
| author_facet |
Yu Ji Hangil Lee Shawn Kaura James Yip Hao Sun Longfei Guan Wei Han Yuchuan Ding |
| author_sort |
Yu Ji |
| title |
Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| title_short |
Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| title_full |
Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| title_fullStr |
Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| title_full_unstemmed |
Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms |
| title_sort |
effect of bariatric surgery on metabolic diseases and underlying mechanisms |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/a7b058943d674ca19f9bd519277487e9 |
| work_keys_str_mv |
AT yuji effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT hangillee effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT shawnkaura effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT jamesyip effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT haosun effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT longfeiguan effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT weihan effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms AT yuchuanding effectofbariatricsurgeryonmetabolicdiseasesandunderlyingmechanisms |
| _version_ |
1718412914815139840 |