Regulation of miR-181a expression in T cell aging

MicroRNA miR-181a has been implicated in the regulation of T cell activation and development. Here the authors show that miR-181a is regulated by a transcription factor, YY1, with reduced YY1 expression linked to reduced miR-181a in old individuals, while silencing YY1 impairs T cell functions large...

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Autores principales:	Zhongde Ye, Guangjin Li, Chulwoo Kim, Bin Hu, Rohit R. Jadhav, Cornelia M. Weyand, Jörg J. Goronzy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7b0dbcfdb714b22a13d1c459e41ea47
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spelling	oai:doaj.org-article:a7b0dbcfdb714b22a13d1c459e41ea472021-12-02T16:49:54ZRegulation of miR-181a expression in T cell aging10.1038/s41467-018-05552-32041-1723https://doaj.org/article/a7b0dbcfdb714b22a13d1c459e41ea472018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05552-3https://doaj.org/toc/2041-1723MicroRNA miR-181a has been implicated in the regulation of T cell activation and development. Here the authors show that miR-181a is regulated by a transcription factor, YY1, with reduced YY1 expression linked to reduced miR-181a in old individuals, while silencing YY1 impairs T cell functions largely through influencing the expression of miR-181a targets.Zhongde YeGuangjin LiChulwoo KimBin HuRohit R. JadhavCornelia M. WeyandJörg J. GoronzyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongde Ye Guangjin Li Chulwoo Kim Bin Hu Rohit R. Jadhav Cornelia M. Weyand Jörg J. Goronzy Regulation of miR-181a expression in T cell aging
description	MicroRNA miR-181a has been implicated in the regulation of T cell activation and development. Here the authors show that miR-181a is regulated by a transcription factor, YY1, with reduced YY1 expression linked to reduced miR-181a in old individuals, while silencing YY1 impairs T cell functions largely through influencing the expression of miR-181a targets.
format	article
author	Zhongde Ye Guangjin Li Chulwoo Kim Bin Hu Rohit R. Jadhav Cornelia M. Weyand Jörg J. Goronzy
author_facet	Zhongde Ye Guangjin Li Chulwoo Kim Bin Hu Rohit R. Jadhav Cornelia M. Weyand Jörg J. Goronzy
author_sort	Zhongde Ye
title	Regulation of miR-181a expression in T cell aging
title_short	Regulation of miR-181a expression in T cell aging
title_full	Regulation of miR-181a expression in T cell aging
title_fullStr	Regulation of miR-181a expression in T cell aging
title_full_unstemmed	Regulation of miR-181a expression in T cell aging
title_sort	regulation of mir-181a expression in t cell aging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a7b0dbcfdb714b22a13d1c459e41ea47
work_keys_str_mv	AT zhongdeye regulationofmir181aexpressionintcellaging AT guangjinli regulationofmir181aexpressionintcellaging AT chulwookim regulationofmir181aexpressionintcellaging AT binhu regulationofmir181aexpressionintcellaging AT rohitrjadhav regulationofmir181aexpressionintcellaging AT corneliamweyand regulationofmir181aexpressionintcellaging AT jorgjgoronzy regulationofmir181aexpressionintcellaging
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Regulation of miR-181a expression in T cell aging

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