Genetics of callous-unemotional behavior in children.

Callous-unemotional behavior (CU) is currently under consideration as a subtyping index for conduct disorder diagnosis. Twin studies routinely estimate the heritability of CU as greater than 50%. It is now possible to estimate genetic influence using DNA alone from samples of unrelated individuals,...

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Autores principales:	Essi Viding, Thomas S Price, Sara R Jaffee, Maciej Trzaskowski, Oliver S P Davis, Emma L Meaburn, Claire M A Haworth, Robert Plomin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7b10a9d7e244d51b314152aefb31d41
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spelling	oai:doaj.org-article:a7b10a9d7e244d51b314152aefb31d412021-11-18T07:38:16ZGenetics of callous-unemotional behavior in children.1932-620310.1371/journal.pone.0065789https://doaj.org/article/a7b10a9d7e244d51b314152aefb31d412013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874384/?tool=EBIhttps://doaj.org/toc/1932-6203Callous-unemotional behavior (CU) is currently under consideration as a subtyping index for conduct disorder diagnosis. Twin studies routinely estimate the heritability of CU as greater than 50%. It is now possible to estimate genetic influence using DNA alone from samples of unrelated individuals, not relying on the assumptions of the twin method. Here we use this new DNA method (implemented in a software package called Genome-wide Complex Trait Analysis, GCTA) for the first time to estimate genetic influence on CU. We also report the first genome-wide association (GWA) study of CU as a quantitative trait. We compare these DNA results to those from twin analyses using the same measure and the same community sample of 2,930 children rated by their teachers at ages 7, 9 and 12. GCTA estimates of heritability were near zero, even though twin analysis of CU in this sample confirmed the high heritability of CU reported in the literature, and even though GCTA estimates of heritability were substantial for cognitive and anthropological traits in this sample. No significant associations were found in GWA analysis, which, like GCTA, only detects additive effects of common DNA variants. The phrase 'missing heritability' was coined to refer to the gap between variance associated with DNA variants identified in GWA studies versus twin study heritability. However, GCTA heritability, not twin study heritability, is the ceiling for GWA studies because both GCTA and GWA are limited to the overall additive effects of common DNA variants, whereas twin studies are not. This GCTA ceiling is very low for CU in our study, despite its high twin study heritability estimate. The gap between GCTA and twin study heritabilities will make it challenging to identify genes responsible for the heritability of CU.Essi VidingThomas S PriceSara R JaffeeMaciej TrzaskowskiOliver S P DavisEmma L MeaburnClaire M A HaworthRobert PlominPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e65789 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Essi Viding Thomas S Price Sara R Jaffee Maciej Trzaskowski Oliver S P Davis Emma L Meaburn Claire M A Haworth Robert Plomin Genetics of callous-unemotional behavior in children.
description	Callous-unemotional behavior (CU) is currently under consideration as a subtyping index for conduct disorder diagnosis. Twin studies routinely estimate the heritability of CU as greater than 50%. It is now possible to estimate genetic influence using DNA alone from samples of unrelated individuals, not relying on the assumptions of the twin method. Here we use this new DNA method (implemented in a software package called Genome-wide Complex Trait Analysis, GCTA) for the first time to estimate genetic influence on CU. We also report the first genome-wide association (GWA) study of CU as a quantitative trait. We compare these DNA results to those from twin analyses using the same measure and the same community sample of 2,930 children rated by their teachers at ages 7, 9 and 12. GCTA estimates of heritability were near zero, even though twin analysis of CU in this sample confirmed the high heritability of CU reported in the literature, and even though GCTA estimates of heritability were substantial for cognitive and anthropological traits in this sample. No significant associations were found in GWA analysis, which, like GCTA, only detects additive effects of common DNA variants. The phrase 'missing heritability' was coined to refer to the gap between variance associated with DNA variants identified in GWA studies versus twin study heritability. However, GCTA heritability, not twin study heritability, is the ceiling for GWA studies because both GCTA and GWA are limited to the overall additive effects of common DNA variants, whereas twin studies are not. This GCTA ceiling is very low for CU in our study, despite its high twin study heritability estimate. The gap between GCTA and twin study heritabilities will make it challenging to identify genes responsible for the heritability of CU.
format	article
author	Essi Viding Thomas S Price Sara R Jaffee Maciej Trzaskowski Oliver S P Davis Emma L Meaburn Claire M A Haworth Robert Plomin
author_facet	Essi Viding Thomas S Price Sara R Jaffee Maciej Trzaskowski Oliver S P Davis Emma L Meaburn Claire M A Haworth Robert Plomin
author_sort	Essi Viding
title	Genetics of callous-unemotional behavior in children.
title_short	Genetics of callous-unemotional behavior in children.
title_full	Genetics of callous-unemotional behavior in children.
title_fullStr	Genetics of callous-unemotional behavior in children.
title_full_unstemmed	Genetics of callous-unemotional behavior in children.
title_sort	genetics of callous-unemotional behavior in children.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a7b10a9d7e244d51b314152aefb31d41
work_keys_str_mv	AT essividing geneticsofcallousunemotionalbehaviorinchildren AT thomassprice geneticsofcallousunemotionalbehaviorinchildren AT sararjaffee geneticsofcallousunemotionalbehaviorinchildren AT maciejtrzaskowski geneticsofcallousunemotionalbehaviorinchildren AT oliverspdavis geneticsofcallousunemotionalbehaviorinchildren AT emmalmeaburn geneticsofcallousunemotionalbehaviorinchildren AT clairemahaworth geneticsofcallousunemotionalbehaviorinchildren AT robertplomin geneticsofcallousunemotionalbehaviorinchildren
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Genetics of callous-unemotional behavior in children.

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