Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, HipSci Consortium, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7b1f1030ed944ff83690e903da90113
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a7b1f1030ed944ff83690e903da90113
record_format	dspace
spelling	oai:doaj.org-article:a7b1f1030ed944ff83690e903da901132021-12-02T14:40:42ZSingle-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression10.1038/s41467-020-14457-z2041-1723https://doaj.org/article/a7b1f1030ed944ff83690e903da901132020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14457-zhttps://doaj.org/toc/2041-1723Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation.Anna S. E. CuomoDaniel D. SeatonDavis J. McCarthyIker MartinezMarc Jan BonderJose Garcia-BernardoShradha AmatyaPedro MadrigalAbigail IsaacsonFlorian BuettnerAndrew KnightsKedar Nath NatarajanHipSci ConsortiumLudovic VallierJohn C. MarioniMariya ChhatriwalaOliver StegleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna S. E. Cuomo Daniel D. Seaton Davis J. McCarthy Iker Martinez Marc Jan Bonder Jose Garcia-Bernardo Shradha Amatya Pedro Madrigal Abigail Isaacson Florian Buettner Andrew Knights Kedar Nath Natarajan HipSci Consortium Ludovic Vallier John C. Marioni Mariya Chhatriwala Oliver Stegle Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
description	Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation.
format	article
author	Anna S. E. Cuomo Daniel D. Seaton Davis J. McCarthy Iker Martinez Marc Jan Bonder Jose Garcia-Bernardo Shradha Amatya Pedro Madrigal Abigail Isaacson Florian Buettner Andrew Knights Kedar Nath Natarajan HipSci Consortium Ludovic Vallier John C. Marioni Mariya Chhatriwala Oliver Stegle
author_facet	Anna S. E. Cuomo Daniel D. Seaton Davis J. McCarthy Iker Martinez Marc Jan Bonder Jose Garcia-Bernardo Shradha Amatya Pedro Madrigal Abigail Isaacson Florian Buettner Andrew Knights Kedar Nath Natarajan HipSci Consortium Ludovic Vallier John C. Marioni Mariya Chhatriwala Oliver Stegle
author_sort	Anna S. E. Cuomo
title	Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
title_short	Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
title_full	Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
title_fullStr	Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
title_full_unstemmed	Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
title_sort	single-cell rna-sequencing of differentiating ips cells reveals dynamic genetic effects on gene expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a7b1f1030ed944ff83690e903da90113
work_keys_str_mv	AT annasecuomo singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT danieldseaton singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT davisjmccarthy singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT ikermartinez singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT marcjanbonder singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT josegarciabernardo singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT shradhaamatya singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT pedromadrigal singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT abigailisaacson singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT florianbuettner singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT andrewknights singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT kedarnathnatarajan singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT hipsciconsortium singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT ludovicvallier singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT johncmarioni singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT mariyachhatriwala singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression AT oliverstegle singlecellrnasequencingofdifferentiatingipscellsrevealsdynamicgeneticeffectsongeneexpression
_version_	1718390190705213440

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Ejemplares similares