Hematopoietic stem cell transplantation for the management of follicular lymphoma

Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: Although much has been published on the application of autologous and allogeneic hematopoietic stem cell transplantation in patients with folli...

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Autor principal:	Chitra Hosing
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/a7b225f385a34a90955ee30e5bef7bba
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spelling	oai:doaj.org-article:a7b225f385a34a90955ee30e5bef7bba2021-12-02T02:50:24ZHematopoietic stem cell transplantation for the management of follicular lymphoma1178-6957https://doaj.org/article/a7b225f385a34a90955ee30e5bef7bba2010-05-01T00:00:00Zhttp://www.dovepress.com/hematopoietic-stem-cell-transplantation-for-the-management-of-follicul-a4352https://doaj.org/toc/1178-6957Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: Although much has been published on the application of autologous and allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma (FL), no uniform consensus exists among physicians on when to use this strategy. Three large randomized trials failed to show a survival benefit using autologous transplantation for FL patients in first complete remission. Similarly, many Phase II or registry-based studies have also failed to show a survival benefit with autologous transplantation in relapsed or refractory FL patients, although the progression-free survival seems to be prolonged in transplant recipients. Allogeneic stem cell transplantation can cure a subset of patients with FL, but high nonrelapse mortality and&nbsp; morbidity remain a concern. No consensus exists on what conditioning regimen should be used,or how the newer monoclonal antibodies should be incorporated into the transplant paradigm. Here we present a review of the role of autologous and allogeneic hematopoietic stem cell transplantation in patients with FL.Keywords: review, follicular lymphoma, allogeneic transplantation, autologous transplantation Chitra HosingDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 69-80 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Chitra Hosing Hematopoietic stem cell transplantation for the management of follicular lymphoma
description	Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: Although much has been published on the application of autologous and allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma (FL), no uniform consensus exists among physicians on when to use this strategy. Three large randomized trials failed to show a survival benefit using autologous transplantation for FL patients in first complete remission. Similarly, many Phase II or registry-based studies have also failed to show a survival benefit with autologous transplantation in relapsed or refractory FL patients, although the progression-free survival seems to be prolonged in transplant recipients. Allogeneic stem cell transplantation can cure a subset of patients with FL, but high nonrelapse mortality and&nbsp; morbidity remain a concern. No consensus exists on what conditioning regimen should be used,or how the newer monoclonal antibodies should be incorporated into the transplant paradigm. Here we present a review of the role of autologous and allogeneic hematopoietic stem cell transplantation in patients with FL.Keywords: review, follicular lymphoma, allogeneic transplantation, autologous transplantation
format	article
author	Chitra Hosing
author_facet	Chitra Hosing
author_sort	Chitra Hosing
title	Hematopoietic stem cell transplantation for the management of follicular lymphoma
title_short	Hematopoietic stem cell transplantation for the management of follicular lymphoma
title_full	Hematopoietic stem cell transplantation for the management of follicular lymphoma
title_fullStr	Hematopoietic stem cell transplantation for the management of follicular lymphoma
title_full_unstemmed	Hematopoietic stem cell transplantation for the management of follicular lymphoma
title_sort	hematopoietic stem cell transplantation for the management of follicular lymphoma
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/a7b225f385a34a90955ee30e5bef7bba
work_keys_str_mv	AT chitrahosing hematopoieticstemcelltransplantationforthemanagementoffollicularlymphoma
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Hematopoietic stem cell transplantation for the management of follicular lymphoma

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