The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.

<h4>Background</h4>The effects of childhood adversities on cognitive function in later life are well reported. However, few studies have examined the cumulative mechanism, especially in Chinese population. This study aims to explore this cumulative effects of childhood adversities on mid...

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Autores principales:	Jing Ma, Yuanyuan Yang, Yang Wan, Chao Shen, Peiyuan Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7b597812dbd48f485a9e5524ce22ae4
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spelling	oai:doaj.org-article:a7b597812dbd48f485a9e5524ce22ae42021-12-02T20:18:04ZThe influence of childhood adversities on mid to late cognitive function: From the perspective of life course.1932-620310.1371/journal.pone.0256297https://doaj.org/article/a7b597812dbd48f485a9e5524ce22ae42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256297https://doaj.org/toc/1932-6203<h4>Background</h4>The effects of childhood adversities on cognitive function in later life are well reported. However, few studies have examined the cumulative mechanism, especially in Chinese population. This study aims to explore this cumulative effects of childhood adversities on mid to late cognitive decline in China.<h4>Methods</h4>Data were drawn from the second and third wave of the China Health and Retirement Longitudinal Study (CHARLS). We included 9,942 respondents aged 45 and above and retrospectively collected information on childhood adversities. Cognitive function was measured in three dimensions: orientation and calculation, immediate memory, and delayed memory. A structural equation model was employed for analysis.<h4>Results</h4>Age (β = -0.155, P<0.001) and mid to late depressive symptoms (β = -0.041, P<0.001) showed direct effects on cognitive decline. Low mid to late life socioeconomic status (SES) showed a direct effect on mid-late cognitive impairment (β = 0.603, P<0.001) and an indirect effect through depression (β = 0.007, P<0.001). Low childhood SES (β = 0.310, P<0.001), lack of friends (β = 0.208, P<0.001), parental mental health problems (β = 0.008, P<0.001), and poor relationship with parents (β = 0.001, P<0.001) had an indirect effect on cognitive impairment.<h4>Conclusions</h4>Childhood adversities had negative effects on cognitive function among middle aged and elderly population in China. The findings suggest that early counter measures on childhood adversities may lead to an effective reduction of cognitive impairment.Jing MaYuanyuan YangYang WanChao ShenPeiyuan QiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256297 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Ma Yuanyuan Yang Yang Wan Chao Shen Peiyuan Qiu The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
description	<h4>Background</h4>The effects of childhood adversities on cognitive function in later life are well reported. However, few studies have examined the cumulative mechanism, especially in Chinese population. This study aims to explore this cumulative effects of childhood adversities on mid to late cognitive decline in China.<h4>Methods</h4>Data were drawn from the second and third wave of the China Health and Retirement Longitudinal Study (CHARLS). We included 9,942 respondents aged 45 and above and retrospectively collected information on childhood adversities. Cognitive function was measured in three dimensions: orientation and calculation, immediate memory, and delayed memory. A structural equation model was employed for analysis.<h4>Results</h4>Age (β = -0.155, P<0.001) and mid to late depressive symptoms (β = -0.041, P<0.001) showed direct effects on cognitive decline. Low mid to late life socioeconomic status (SES) showed a direct effect on mid-late cognitive impairment (β = 0.603, P<0.001) and an indirect effect through depression (β = 0.007, P<0.001). Low childhood SES (β = 0.310, P<0.001), lack of friends (β = 0.208, P<0.001), parental mental health problems (β = 0.008, P<0.001), and poor relationship with parents (β = 0.001, P<0.001) had an indirect effect on cognitive impairment.<h4>Conclusions</h4>Childhood adversities had negative effects on cognitive function among middle aged and elderly population in China. The findings suggest that early counter measures on childhood adversities may lead to an effective reduction of cognitive impairment.
format	article
author	Jing Ma Yuanyuan Yang Yang Wan Chao Shen Peiyuan Qiu
author_facet	Jing Ma Yuanyuan Yang Yang Wan Chao Shen Peiyuan Qiu
author_sort	Jing Ma
title	The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
title_short	The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
title_full	The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
title_fullStr	The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
title_full_unstemmed	The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
title_sort	influence of childhood adversities on mid to late cognitive function: from the perspective of life course.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a7b597812dbd48f485a9e5524ce22ae4
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The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.

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