Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.

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Autores principales:	Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7b5b9da2b7f453a828d4e919ce3ab01
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spelling	oai:doaj.org-article:a7b5b9da2b7f453a828d4e919ce3ab012021-12-02T14:06:16ZStructural basis for ligand recognition of the neuropeptide Y Y2 receptor10.1038/s41467-021-21030-92041-1723https://doaj.org/article/a7b5b9da2b7f453a828d4e919ce3ab012021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21030-9https://doaj.org/toc/2041-1723The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.Tingting TangChristin HartigQiuru ChenWenli ZhaoAnette KaiserXuefeng ZhangHui ZhangHonge QuCuiying YiLimin MaShuo HanQiang ZhaoAnnette G. Beck-SickingerBeili WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tingting Tang Christin Hartig Qiuru Chen Wenli Zhao Anette Kaiser Xuefeng Zhang Hui Zhang Honge Qu Cuiying Yi Limin Ma Shuo Han Qiang Zhao Annette G. Beck-Sickinger Beili Wu Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
description	The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.
format	article
author	Tingting Tang Christin Hartig Qiuru Chen Wenli Zhao Anette Kaiser Xuefeng Zhang Hui Zhang Honge Qu Cuiying Yi Limin Ma Shuo Han Qiang Zhao Annette G. Beck-Sickinger Beili Wu
author_facet	Tingting Tang Christin Hartig Qiuru Chen Wenli Zhao Anette Kaiser Xuefeng Zhang Hui Zhang Honge Qu Cuiying Yi Limin Ma Shuo Han Qiang Zhao Annette G. Beck-Sickinger Beili Wu
author_sort	Tingting Tang
title	Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
title_short	Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
title_full	Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
title_fullStr	Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
title_full_unstemmed	Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
title_sort	structural basis for ligand recognition of the neuropeptide y y2 receptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7b5b9da2b7f453a828d4e919ce3ab01
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Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

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