Hepatobiliary phenotype of individuals with chronic intestinal disorders

Abstract Despite the known functional relationship between the gut and the liver, the clinical consequences of this circuit remain unclear. We assessed the hepatobiliary phenotype of cohorts with celiac disease (CeD), Crohn´s disease (CD) and ulcerative colitis (UC). Baseline liver function tests an...

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Autores principales:	Jessica Voss, Carolin V. Schneider, Moritz Kleinjans, Tony Bruns, Christian Trautwein, Pavel Strnad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7baa8166d4a4a0ca379e4a2e713d218
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spelling	oai:doaj.org-article:a7baa8166d4a4a0ca379e4a2e713d2182021-12-02T17:13:18ZHepatobiliary phenotype of individuals with chronic intestinal disorders10.1038/s41598-021-98843-72045-2322https://doaj.org/article/a7baa8166d4a4a0ca379e4a2e713d2182021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98843-7https://doaj.org/toc/2045-2322Abstract Despite the known functional relationship between the gut and the liver, the clinical consequences of this circuit remain unclear. We assessed the hepatobiliary phenotype of cohorts with celiac disease (CeD), Crohn´s disease (CD) and ulcerative colitis (UC). Baseline liver function tests and the frequency of hepatobiliary diseases were analyzed in 2377 CeD, 1738 CD, 3684 UC subjects and 488,941 controls from the population-based UK Biobank cohort. In this cohort study associations were adjusted for age, sex, BMI, diabetes, and alcohol consumption. Compared to controls, cohorts with CeD, but not CD/UC displayed higher AST/ALT values. Subjects with CD/UC but not CeD had increased GGT levels. Elevated ALP and cholelithiasis were significantly more common in all intestinal disorders. Non-alcoholic steatohepatitis and hepatocellular carcinoma (HCC) were enriched in CeD and CD (NASH: taOR = 4.9 [2.2–11.0] in CeD, aOR = 4.2 [1.7–10.3] in CD, HCC: aOR = 4.8 [1.8–13.0] in CeD, aOR = 5.9 [2.2–16.1] in CD), while cholangitis was more common in the CD/UC cohorts (aOR = 11.7 [9.1–15.0] in UC, aOR = 3.5 [1.8–6.8] in CD). Chronic hepatitis, autoimmune hepatitis (AIH) and cirrhosis were more prevalent in all intestinal disorders. In UC/CD, a history of intestinal surgery was associated with elevated liver enzymes and increased occurrence of gallstones (UC: aOR = 2.9 [2.1–4.1], CD: 1.7 [1.2–2.3]). Our data demonstrate that different intestinal disorders predispose to distinct hepatobiliary phenotypes. An increased occurrence of liver cirrhosis, NASH, AIH and HCC and the impact of surgery warrant further exploration.Jessica VossCarolin V. SchneiderMoritz KleinjansTony BrunsChristian TrautweinPavel StrnadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jessica Voss Carolin V. Schneider Moritz Kleinjans Tony Bruns Christian Trautwein Pavel Strnad Hepatobiliary phenotype of individuals with chronic intestinal disorders
description	Abstract Despite the known functional relationship between the gut and the liver, the clinical consequences of this circuit remain unclear. We assessed the hepatobiliary phenotype of cohorts with celiac disease (CeD), Crohn´s disease (CD) and ulcerative colitis (UC). Baseline liver function tests and the frequency of hepatobiliary diseases were analyzed in 2377 CeD, 1738 CD, 3684 UC subjects and 488,941 controls from the population-based UK Biobank cohort. In this cohort study associations were adjusted for age, sex, BMI, diabetes, and alcohol consumption. Compared to controls, cohorts with CeD, but not CD/UC displayed higher AST/ALT values. Subjects with CD/UC but not CeD had increased GGT levels. Elevated ALP and cholelithiasis were significantly more common in all intestinal disorders. Non-alcoholic steatohepatitis and hepatocellular carcinoma (HCC) were enriched in CeD and CD (NASH: taOR = 4.9 [2.2–11.0] in CeD, aOR = 4.2 [1.7–10.3] in CD, HCC: aOR = 4.8 [1.8–13.0] in CeD, aOR = 5.9 [2.2–16.1] in CD), while cholangitis was more common in the CD/UC cohorts (aOR = 11.7 [9.1–15.0] in UC, aOR = 3.5 [1.8–6.8] in CD). Chronic hepatitis, autoimmune hepatitis (AIH) and cirrhosis were more prevalent in all intestinal disorders. In UC/CD, a history of intestinal surgery was associated with elevated liver enzymes and increased occurrence of gallstones (UC: aOR = 2.9 [2.1–4.1], CD: 1.7 [1.2–2.3]). Our data demonstrate that different intestinal disorders predispose to distinct hepatobiliary phenotypes. An increased occurrence of liver cirrhosis, NASH, AIH and HCC and the impact of surgery warrant further exploration.
format	article
author	Jessica Voss Carolin V. Schneider Moritz Kleinjans Tony Bruns Christian Trautwein Pavel Strnad
author_facet	Jessica Voss Carolin V. Schneider Moritz Kleinjans Tony Bruns Christian Trautwein Pavel Strnad
author_sort	Jessica Voss
title	Hepatobiliary phenotype of individuals with chronic intestinal disorders
title_short	Hepatobiliary phenotype of individuals with chronic intestinal disorders
title_full	Hepatobiliary phenotype of individuals with chronic intestinal disorders
title_fullStr	Hepatobiliary phenotype of individuals with chronic intestinal disorders
title_full_unstemmed	Hepatobiliary phenotype of individuals with chronic intestinal disorders
title_sort	hepatobiliary phenotype of individuals with chronic intestinal disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7baa8166d4a4a0ca379e4a2e713d218
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Hepatobiliary phenotype of individuals with chronic intestinal disorders

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