Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs

Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and is the leading cause of cancer mortality in Vietnam. Our study aims to discover the partial extracts with the potential cytotoxic effects on HCC cells from the different parts of 24 Vietnamese medicinal plants tradi...

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Autores principales:	Hien Minh Nguyen, Nhi Yen Thi Nguyen, Nghia Trong Ngoc Chau, Anh Bao Thi Nguyen, Van Kieu Thi Tran, Viet Hoang, Tri Minh Le, Hui-Chun Wang, Chia-Hung Yen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Luvunga scandens</i> <i>Hyptis suaveolens</i> <i>Solanum torvum</i> Huh-7 cells cytotoxic activity antioxidant Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a7bd987df60742f69271a7b108601993
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spelling	oai:doaj.org-article:a7bd987df60742f69271a7b1086019932021-11-25T18:50:45ZBioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs10.3390/pr91119562227-9717https://doaj.org/article/a7bd987df60742f69271a7b1086019932021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/1956https://doaj.org/toc/2227-9717Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and is the leading cause of cancer mortality in Vietnam. Our study aims to discover the partial extracts with the potential cytotoxic effects on HCC cells from the different parts of 24 Vietnamese medicinal plants traditionally used in liver cancer treatment. Out of 52 crude methanol extracts, we found that <i>Luvunga scandens</i> leaves, <i>Hyptis suaveolens</i> roots, and <i>Solanum torvum</i> leaves showed the notable cytotoxic effects against HCC cells. After that, we carried out partial extract of the three methanol extracts with ethyl acetate, water, <i>n-</i>hexane, and 90% methanol. The cytotoxic activity on Huh-7 HCC cells, antioxidant capacity, and total flavonoids content (TFC) of each partial extraction were determined. Methanol, ethyl acetate, and 90% methanol extracts showed moderate to strong cytotoxicity activity against Huh-7 HCC cells. Notably, the ethyl acetate and 90% methanol extract from <i>H. suaveolens</i> roots with high TFC values and strong antioxidant capacity could be promising sources of novel therapeutic modalities for HCC treatment. For the leaves of <i>L. scandens</i> and <i>S. torvum</i>, the ethyl acetate extract showed high TFC value and promising anti-HCC activity, therefore recommended further studies.Hien Minh NguyenNhi Yen Thi NguyenNghia Trong Ngoc ChauAnh Bao Thi NguyenVan Kieu Thi TranViet HoangTri Minh LeHui-Chun WangChia-Hung YenMDPI AGarticle<i>Luvunga scandens</i><i>Hyptis suaveolens</i><i>Solanum torvum</i>Huh-7 cellscytotoxic activityantioxidantChemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 1956, p 1956 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Luvunga scandens</i> <i>Hyptis suaveolens</i> <i>Solanum torvum</i> Huh-7 cells cytotoxic activity antioxidant Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	<i>Luvunga scandens</i> <i>Hyptis suaveolens</i> <i>Solanum torvum</i> Huh-7 cells cytotoxic activity antioxidant Chemical technology TP1-1185 Chemistry QD1-999 Hien Minh Nguyen Nhi Yen Thi Nguyen Nghia Trong Ngoc Chau Anh Bao Thi Nguyen Van Kieu Thi Tran Viet Hoang Tri Minh Le Hui-Chun Wang Chia-Hung Yen Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
description	Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and is the leading cause of cancer mortality in Vietnam. Our study aims to discover the partial extracts with the potential cytotoxic effects on HCC cells from the different parts of 24 Vietnamese medicinal plants traditionally used in liver cancer treatment. Out of 52 crude methanol extracts, we found that <i>Luvunga scandens</i> leaves, <i>Hyptis suaveolens</i> roots, and <i>Solanum torvum</i> leaves showed the notable cytotoxic effects against HCC cells. After that, we carried out partial extract of the three methanol extracts with ethyl acetate, water, <i>n-</i>hexane, and 90% methanol. The cytotoxic activity on Huh-7 HCC cells, antioxidant capacity, and total flavonoids content (TFC) of each partial extraction were determined. Methanol, ethyl acetate, and 90% methanol extracts showed moderate to strong cytotoxicity activity against Huh-7 HCC cells. Notably, the ethyl acetate and 90% methanol extract from <i>H. suaveolens</i> roots with high TFC values and strong antioxidant capacity could be promising sources of novel therapeutic modalities for HCC treatment. For the leaves of <i>L. scandens</i> and <i>S. torvum</i>, the ethyl acetate extract showed high TFC value and promising anti-HCC activity, therefore recommended further studies.
format	article
author	Hien Minh Nguyen Nhi Yen Thi Nguyen Nghia Trong Ngoc Chau Anh Bao Thi Nguyen Van Kieu Thi Tran Viet Hoang Tri Minh Le Hui-Chun Wang Chia-Hung Yen
author_facet	Hien Minh Nguyen Nhi Yen Thi Nguyen Nghia Trong Ngoc Chau Anh Bao Thi Nguyen Van Kieu Thi Tran Viet Hoang Tri Minh Le Hui-Chun Wang Chia-Hung Yen
author_sort	Hien Minh Nguyen
title	Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
title_short	Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
title_full	Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
title_fullStr	Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
title_full_unstemmed	Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs
title_sort	bioassay-guided discovery of potential partial extracts with cytotoxic effects on liver cancer cells from vietnamese medicinal herbs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a7bd987df60742f69271a7b108601993
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Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs

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