Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response in the absence of membrane tension.

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Autores principales:	Charalampos Kapsalis, Bolin Wang, Hassane El Mkami, Samantha J. Pitt, Jason R. Schnell, Terry K. Smith, Jonathan D. Lippiat, Bela E. Bode, Christos Pliotas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7be892017b649e08e44a9f92049a42a
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spelling	oai:doaj.org-article:a7be892017b649e08e44a9f92049a42a2021-12-02T14:40:18ZAllosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets10.1038/s41467-019-12591-x2041-1723https://doaj.org/article/a7be892017b649e08e44a9f92049a42a2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12591-xhttps://doaj.org/toc/2041-1723How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response in the absence of membrane tension.Charalampos KapsalisBolin WangHassane El MkamiSamantha J. PittJason R. SchnellTerry K. SmithJonathan D. LippiatBela E. BodeChristos PliotasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charalampos Kapsalis Bolin Wang Hassane El Mkami Samantha J. Pitt Jason R. Schnell Terry K. Smith Jonathan D. Lippiat Bela E. Bode Christos Pliotas Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
description	How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response in the absence of membrane tension.
format	article
author	Charalampos Kapsalis Bolin Wang Hassane El Mkami Samantha J. Pitt Jason R. Schnell Terry K. Smith Jonathan D. Lippiat Bela E. Bode Christos Pliotas
author_facet	Charalampos Kapsalis Bolin Wang Hassane El Mkami Samantha J. Pitt Jason R. Schnell Terry K. Smith Jonathan D. Lippiat Bela E. Bode Christos Pliotas
author_sort	Charalampos Kapsalis
title	Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
title_short	Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
title_full	Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
title_fullStr	Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
title_full_unstemmed	Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
title_sort	allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a7be892017b649e08e44a9f92049a42a
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Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

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