Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.

The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiote...

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Autores principales:	Deniz Cizmeci, Yaman Arkun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f481
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spelling	oai:doaj.org-article:a7c0458bb7934aaabb0e9b46c669f4812021-11-18T08:39:11ZRegulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.1932-620310.1371/journal.pone.0083640https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f4812013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400038/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.Deniz CizmeciYaman ArkunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83640 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deniz Cizmeci Yaman Arkun Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
description	The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.
format	article
author	Deniz Cizmeci Yaman Arkun
author_facet	Deniz Cizmeci Yaman Arkun
author_sort	Deniz Cizmeci
title	Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_short	Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full	Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_fullStr	Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full_unstemmed	Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_sort	regulatory networks and complex interactions between the insulin and angiotensin ii signalling systems: models and implications for hypertension and diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f481
work_keys_str_mv	AT denizcizmeci regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes AT yamanarkun regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes
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Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.

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