Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.

The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiote...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Deniz Cizmeci, Yaman Arkun
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
R
Q
Acceso en línea:https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f481
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a7c0458bb7934aaabb0e9b46c669f481
record_format dspace
spelling oai:doaj.org-article:a7c0458bb7934aaabb0e9b46c669f4812021-11-18T08:39:11ZRegulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.1932-620310.1371/journal.pone.0083640https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f4812013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400038/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.Deniz CizmeciYaman ArkunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83640 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Deniz Cizmeci
Yaman Arkun
Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
description The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.
format article
author Deniz Cizmeci
Yaman Arkun
author_facet Deniz Cizmeci
Yaman Arkun
author_sort Deniz Cizmeci
title Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_short Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_fullStr Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full_unstemmed Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_sort regulatory networks and complex interactions between the insulin and angiotensin ii signalling systems: models and implications for hypertension and diabetes.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/a7c0458bb7934aaabb0e9b46c669f481
work_keys_str_mv AT denizcizmeci regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes
AT yamanarkun regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes
_version_ 1718421519979249664