I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels.

The intracellular loops that interlink the four transmembrane domains of Ca(2+)- and Na(+)-channels (Ca(v), Na(v)) have critical roles in numerous forms of channel regulation. In particular, the intracellular loop that joins repeats I and II (I-II loop) in high voltage-activated (HVA) Ca(2+) channel...

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Autores principales: Joel P Baumgart, Iuliia Vitko, Isabelle Bidaud, Artem Kondratskyi, Philippe Lory, Edward Perez-Reyes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
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Acceso en línea:https://doaj.org/article/a7c1bc0a7af04ff799dfaf61a90642da
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