Indocyanine Green for Leakage Control in Isolated Limb Perfusion

Sarcomas are characterized by a high metastatic potential and aggressive growth. Despite surgery, chemotherapy plays an important role in the treatment of these tumors. Optimal anti-cancer therapy with maximized local efficacy and minimized systemic side effects has been the object of many studies f...

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Autores principales:	Isabel Zucal, Sebastian Geis, Lukas Prantl, Silke Haerteis, Thiha Aung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytostatic agents doxorubicin indocyanine green oncology perfusion surgical oncology Medicine R
Acceso en línea:	https://doaj.org/article/a7cae02e347545ed8bc1ea148050daf5
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spelling	oai:doaj.org-article:a7cae02e347545ed8bc1ea148050daf52021-11-25T18:07:35ZIndocyanine Green for Leakage Control in Isolated Limb Perfusion10.3390/jpm111111522075-4426https://doaj.org/article/a7cae02e347545ed8bc1ea148050daf52021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1152https://doaj.org/toc/2075-4426Sarcomas are characterized by a high metastatic potential and aggressive growth. Despite surgery, chemotherapy plays an important role in the treatment of these tumors. Optimal anti-cancer therapy with maximized local efficacy and minimized systemic side effects has been the object of many studies for a long time. To improve the local efficacy of anti-tumor therapy, isolated limb perfusion with high-dose cytostatic agents has been introduced in surgical oncology. In order to control the local distribution of substances, radiolabeled cytostatic drugs or perfusion solutions have been applied but often require the presence of specialized personnel and result in a certain exposure to radiation. In this study, we present a novel strategy using indocyanine green to track tumor perfusion with high-dose cytostatic therapy. In a rat cadaver model, the femoral vessels were cannulated and connected to a peristaltic pump to provide circulation within the selected limb. The perfusion solution contained indocyanine green and high-dose doxorubicin. An infrared camera enabled the visualization of indocyanine green during limb perfusion, and subsequent leakage control was successfully performed. Histologic analysis of sections derived proximally from the injection site excluded systemic drug dispersion. In this study, the application of indocyanine green was proven to be a safe and cost- and time-efficient method for precise leakage control in isolated limb perfusion with a high-dose cytostatic agent.Isabel ZucalSebastian GeisLukas PrantlSilke HaerteisThiha AungMDPI AGarticlecytostatic agentsdoxorubicinindocyanine greenoncologyperfusionsurgical oncologyMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1152, p 1152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytostatic agents doxorubicin indocyanine green oncology perfusion surgical oncology Medicine R
spellingShingle	cytostatic agents doxorubicin indocyanine green oncology perfusion surgical oncology Medicine R Isabel Zucal Sebastian Geis Lukas Prantl Silke Haerteis Thiha Aung Indocyanine Green for Leakage Control in Isolated Limb Perfusion
description	Sarcomas are characterized by a high metastatic potential and aggressive growth. Despite surgery, chemotherapy plays an important role in the treatment of these tumors. Optimal anti-cancer therapy with maximized local efficacy and minimized systemic side effects has been the object of many studies for a long time. To improve the local efficacy of anti-tumor therapy, isolated limb perfusion with high-dose cytostatic agents has been introduced in surgical oncology. In order to control the local distribution of substances, radiolabeled cytostatic drugs or perfusion solutions have been applied but often require the presence of specialized personnel and result in a certain exposure to radiation. In this study, we present a novel strategy using indocyanine green to track tumor perfusion with high-dose cytostatic therapy. In a rat cadaver model, the femoral vessels were cannulated and connected to a peristaltic pump to provide circulation within the selected limb. The perfusion solution contained indocyanine green and high-dose doxorubicin. An infrared camera enabled the visualization of indocyanine green during limb perfusion, and subsequent leakage control was successfully performed. Histologic analysis of sections derived proximally from the injection site excluded systemic drug dispersion. In this study, the application of indocyanine green was proven to be a safe and cost- and time-efficient method for precise leakage control in isolated limb perfusion with a high-dose cytostatic agent.
format	article
author	Isabel Zucal Sebastian Geis Lukas Prantl Silke Haerteis Thiha Aung
author_facet	Isabel Zucal Sebastian Geis Lukas Prantl Silke Haerteis Thiha Aung
author_sort	Isabel Zucal
title	Indocyanine Green for Leakage Control in Isolated Limb Perfusion
title_short	Indocyanine Green for Leakage Control in Isolated Limb Perfusion
title_full	Indocyanine Green for Leakage Control in Isolated Limb Perfusion
title_fullStr	Indocyanine Green for Leakage Control in Isolated Limb Perfusion
title_full_unstemmed	Indocyanine Green for Leakage Control in Isolated Limb Perfusion
title_sort	indocyanine green for leakage control in isolated limb perfusion
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a7cae02e347545ed8bc1ea148050daf5
work_keys_str_mv	AT isabelzucal indocyaninegreenforleakagecontrolinisolatedlimbperfusion AT sebastiangeis indocyaninegreenforleakagecontrolinisolatedlimbperfusion AT lukasprantl indocyaninegreenforleakagecontrolinisolatedlimbperfusion AT silkehaerteis indocyaninegreenforleakagecontrolinisolatedlimbperfusion AT thihaaung indocyaninegreenforleakagecontrolinisolatedlimbperfusion
_version_	1718411634141036544

Indocyanine Green for Leakage Control in Isolated Limb Perfusion

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