An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children

Abstract Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated...

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Autores principales:	Sofia Moran-Ramos, Elvira Ocampo-Medina, Ruth Gutierrez-Aguilar, Luis Macías-Kauffer, Hugo Villamil-Ramírez, Blanca E. López-Contreras, Paola León-Mimila, Joel Vega-Badillo, Roxana Gutierrez-Vidal, Ricardo Villarruel-Vazquez, Erandi Serrano-Carbajal, Blanca E Del-Río-Navarro, Adriana Huertas-Vázquez, Teresa Villarreal-Molina, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Carlos A. Aguilar-Salinas, Samuel Canizales-Quinteros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7cb1758d82c4320af29cfa439624b9b
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spelling	oai:doaj.org-article:a7cb1758d82c4320af29cfa439624b9b2021-12-02T11:40:33ZAn Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children10.1038/s41598-017-05765-42045-2322https://doaj.org/article/a7cb1758d82c4320af29cfa439624b9b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05765-4https://doaj.org/toc/2045-2322Abstract Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6–12-year-old children. Forty-two metabolites were measured using electrospray MS/MS and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical and biochemical parameters. Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity (OR = 1.57; 95%CI 1.45–1.69, P = 3.84 × 10−31) and serum triglycerides (TG) (β = 0.067, P = 4.5 × 10−21). These associations were validated in the cross-sectional study (P < 0.0001). In the longitudinal cohort, the amino acid signature was associated with serum TG and with the risk of hypertriglyceridemia after 2 years (OR = 1.19; 95%CI 1.03-1.39, P = 0.016). This study shows that an amino acid signature significantly associated with childhood obesity, is an independent risk factor of future hypertriglyceridemia in children.Sofia Moran-RamosElvira Ocampo-MedinaRuth Gutierrez-AguilarLuis Macías-KaufferHugo Villamil-RamírezBlanca E. López-ContrerasPaola León-MimilaJoel Vega-BadilloRoxana Gutierrez-VidalRicardo Villarruel-VazquezErandi Serrano-CarbajalBlanca E Del-Río-NavarroAdriana Huertas-VázquezTeresa Villarreal-MolinaIsabel Ibarra-GonzalezMarcela Vela-AmievaCarlos A. Aguilar-SalinasSamuel Canizales-QuinterosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sofia Moran-Ramos Elvira Ocampo-Medina Ruth Gutierrez-Aguilar Luis Macías-Kauffer Hugo Villamil-Ramírez Blanca E. López-Contreras Paola León-Mimila Joel Vega-Badillo Roxana Gutierrez-Vidal Ricardo Villarruel-Vazquez Erandi Serrano-Carbajal Blanca E Del-Río-Navarro Adriana Huertas-Vázquez Teresa Villarreal-Molina Isabel Ibarra-Gonzalez Marcela Vela-Amieva Carlos A. Aguilar-Salinas Samuel Canizales-Quinteros An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
description	Abstract Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6–12-year-old children. Forty-two metabolites were measured using electrospray MS/MS and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical and biochemical parameters. Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity (OR = 1.57; 95%CI 1.45–1.69, P = 3.84 × 10−31) and serum triglycerides (TG) (β = 0.067, P = 4.5 × 10−21). These associations were validated in the cross-sectional study (P < 0.0001). In the longitudinal cohort, the amino acid signature was associated with serum TG and with the risk of hypertriglyceridemia after 2 years (OR = 1.19; 95%CI 1.03-1.39, P = 0.016). This study shows that an amino acid signature significantly associated with childhood obesity, is an independent risk factor of future hypertriglyceridemia in children.
format	article
author	Sofia Moran-Ramos Elvira Ocampo-Medina Ruth Gutierrez-Aguilar Luis Macías-Kauffer Hugo Villamil-Ramírez Blanca E. López-Contreras Paola León-Mimila Joel Vega-Badillo Roxana Gutierrez-Vidal Ricardo Villarruel-Vazquez Erandi Serrano-Carbajal Blanca E Del-Río-Navarro Adriana Huertas-Vázquez Teresa Villarreal-Molina Isabel Ibarra-Gonzalez Marcela Vela-Amieva Carlos A. Aguilar-Salinas Samuel Canizales-Quinteros
author_facet	Sofia Moran-Ramos Elvira Ocampo-Medina Ruth Gutierrez-Aguilar Luis Macías-Kauffer Hugo Villamil-Ramírez Blanca E. López-Contreras Paola León-Mimila Joel Vega-Badillo Roxana Gutierrez-Vidal Ricardo Villarruel-Vazquez Erandi Serrano-Carbajal Blanca E Del-Río-Navarro Adriana Huertas-Vázquez Teresa Villarreal-Molina Isabel Ibarra-Gonzalez Marcela Vela-Amieva Carlos A. Aguilar-Salinas Samuel Canizales-Quinteros
author_sort	Sofia Moran-Ramos
title	An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
title_short	An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
title_full	An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
title_fullStr	An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
title_full_unstemmed	An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
title_sort	amino acid signature associated with obesity predicts 2-year risk of hypertriglyceridemia in school-age children
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a7cb1758d82c4320af29cfa439624b9b
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An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children

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