Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes

The number of patients afflicted by type 2 diabetes and its morbidities has increased alarmingly, becoming the cause of many deaths. Normally, during nutrient intake, insulin secretion is increased and glucagon secretion is repressed, but when plasma glucose concentration increases, a state of predi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martha Lucinda Contreras-Zentella, Rolando Hernández-Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 2 diabetes gender oxidative stress inflammation metabolomics obesity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a7cc26ecc31b4ee795780f0213614213
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a7cc26ecc31b4ee795780f0213614213
record_format	dspace
spelling	oai:doaj.org-article:a7cc26ecc31b4ee795780f02136142132021-11-25T16:27:18ZPossible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes10.3390/antiox101117292076-3921https://doaj.org/article/a7cc26ecc31b4ee795780f02136142132021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1729https://doaj.org/toc/2076-3921The number of patients afflicted by type 2 diabetes and its morbidities has increased alarmingly, becoming the cause of many deaths. Normally, during nutrient intake, insulin secretion is increased and glucagon secretion is repressed, but when plasma glucose concentration increases, a state of prediabetes occurs. High concentration of plasma glucose breaks the redox balance, inducing an oxidative stress that promotes chronic inflammation, insulin resistance, and impaired insulin secretion. In the same context, obesity is one of the most crucial factors inducing insulin resistance, inflammation, and contributing to the onset of type 2 diabetes. Measurements of metabolites like glucose, fructose, amino acids, and lipids exhibit significant predictive associations with type 2 diabetes or a prediabetes state and lead to changes in plasma metabolites that could be selectively affected by gender and age. In terms of gender, women and men have biological dissimilarities that might have an important role for the development, diagnosis, therapy, and prevention of type 2 diabetes, obesity, and relevant hazards in both genders, for type 2 diabetes. Therefore, the present review attempts to analyze the influence of gender on the relationships among inflammatory events, oxidative stress, and metabolic alterations in patients undergoing obesity and/or type 2 diabetes.Martha Lucinda Contreras-ZentellaRolando Hernández-MuñozMDPI AGarticletype 2 diabetesgenderoxidative stressinflammationmetabolomicsobesityTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1729, p 1729 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes gender oxidative stress inflammation metabolomics obesity Therapeutics. Pharmacology RM1-950
spellingShingle	type 2 diabetes gender oxidative stress inflammation metabolomics obesity Therapeutics. Pharmacology RM1-950 Martha Lucinda Contreras-Zentella Rolando Hernández-Muñoz Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
description	The number of patients afflicted by type 2 diabetes and its morbidities has increased alarmingly, becoming the cause of many deaths. Normally, during nutrient intake, insulin secretion is increased and glucagon secretion is repressed, but when plasma glucose concentration increases, a state of prediabetes occurs. High concentration of plasma glucose breaks the redox balance, inducing an oxidative stress that promotes chronic inflammation, insulin resistance, and impaired insulin secretion. In the same context, obesity is one of the most crucial factors inducing insulin resistance, inflammation, and contributing to the onset of type 2 diabetes. Measurements of metabolites like glucose, fructose, amino acids, and lipids exhibit significant predictive associations with type 2 diabetes or a prediabetes state and lead to changes in plasma metabolites that could be selectively affected by gender and age. In terms of gender, women and men have biological dissimilarities that might have an important role for the development, diagnosis, therapy, and prevention of type 2 diabetes, obesity, and relevant hazards in both genders, for type 2 diabetes. Therefore, the present review attempts to analyze the influence of gender on the relationships among inflammatory events, oxidative stress, and metabolic alterations in patients undergoing obesity and/or type 2 diabetes.
format	article
author	Martha Lucinda Contreras-Zentella Rolando Hernández-Muñoz
author_facet	Martha Lucinda Contreras-Zentella Rolando Hernández-Muñoz
author_sort	Martha Lucinda Contreras-Zentella
title	Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
title_short	Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
title_full	Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
title_fullStr	Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
title_full_unstemmed	Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
title_sort	possible gender influence in the mechanisms underlying the oxidative stress, inflammatory response, and the metabolic alterations in patients with obesity and/or type 2 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a7cc26ecc31b4ee795780f0213614213
work_keys_str_mv	AT marthalucindacontreraszentella possiblegenderinfluenceinthemechanismsunderlyingtheoxidativestressinflammatoryresponseandthemetabolicalterationsinpatientswithobesityandortype2diabetes AT rolandohernandezmunoz possiblegenderinfluenceinthemechanismsunderlyingtheoxidativestressinflammatoryresponseandthemetabolicalterationsinpatientswithobesityandortype2diabetes
_version_	1718413157632835584

Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes

Ejemplares similares