Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output

Abstract Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address existing limitations in the gas analysis, we developed an in-airway analyser based on laser absorption spectroscopy to provide analyses ev...

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Autores principales:	Nicholas M. J. Smith, John Couper, Graham Richmond, Dominic Sandhu, Gus Hancock, Peter A. Robbins, Grant A. D. Ritchie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7ccd83ab1054a6e8a63eac116fd5331
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spelling	oai:doaj.org-article:a7ccd83ab1054a6e8a63eac116fd53312021-12-02T15:54:06ZDevelopment of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output10.1038/s41598-021-84649-02045-2322https://doaj.org/article/a7ccd83ab1054a6e8a63eac116fd53312021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84649-0https://doaj.org/toc/2045-2322Abstract Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address existing limitations in the gas analysis, we developed an in-airway analyser based on laser absorption spectroscopy to provide analyses every 10 ms. The technique for estimating cardiac output requires both a relatively soluble and insoluble tracer gas, and we employed acetylene and methane for these, respectively. A multipass cell was used to provide sufficient measurement sensitivity to enable analysis directly within the main gas stream, thus avoiding errors introduced by sidestream gas analysis. To assess performance, measurements of cardiac output were made during both rest and exercise on five successive days in each of six volunteers. The measurements were extremely repeatable (coefficient of variation ~ 7%). This new measurement technology provides a stable foundation against which the algorithm to calculate cardiac output can be further developed.Nicholas M. J. SmithJohn CouperGraham RichmondDominic SandhuGus HancockPeter A. RobbinsGrant A. D. RitchieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicholas M. J. Smith John Couper Graham Richmond Dominic Sandhu Gus Hancock Peter A. Robbins Grant A. D. Ritchie Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
description	Abstract Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address existing limitations in the gas analysis, we developed an in-airway analyser based on laser absorption spectroscopy to provide analyses every 10 ms. The technique for estimating cardiac output requires both a relatively soluble and insoluble tracer gas, and we employed acetylene and methane for these, respectively. A multipass cell was used to provide sufficient measurement sensitivity to enable analysis directly within the main gas stream, thus avoiding errors introduced by sidestream gas analysis. To assess performance, measurements of cardiac output were made during both rest and exercise on five successive days in each of six volunteers. The measurements were extremely repeatable (coefficient of variation ~ 7%). This new measurement technology provides a stable foundation against which the algorithm to calculate cardiac output can be further developed.
format	article
author	Nicholas M. J. Smith John Couper Graham Richmond Dominic Sandhu Gus Hancock Peter A. Robbins Grant A. D. Ritchie
author_facet	Nicholas M. J. Smith John Couper Graham Richmond Dominic Sandhu Gus Hancock Peter A. Robbins Grant A. D. Ritchie
author_sort	Nicholas M. J. Smith
title	Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
title_short	Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
title_full	Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
title_fullStr	Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
title_full_unstemmed	Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
title_sort	development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7ccd83ab1054a6e8a63eac116fd5331
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Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output

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