Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents

Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, 1HNMR and 13CNMR. The compounds were checked f...

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Autores principales:	Anees Pangal, Yusufi Mujahid, Bajarang Desai, Javed A. Shaikh, Khursheed Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Growing Science 2022
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a7d048a987514ad3be380889d499943f
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spelling	oai:doaj.org-article:a7d048a987514ad3be380889d499943f2021-11-12T12:52:42ZSynthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents1927-72961927-730X10.5267/j.ccl.2021.8.004https://doaj.org/article/a7d048a987514ad3be380889d499943f2022-01-01T00:00:00Zhttp://www.growingscience.com/ccl/Vol11/ccl_2021_31.pdfhttps://doaj.org/toc/1927-7296https://doaj.org/toc/1927-730X Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, 1HNMR and 13CNMR. The compounds were checked for their in vitro anticancer activities against three different human cancer cell lines viz human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human oral squamous cell carcinoma (SCC-40) using SRB method. All the title compounds showed low toxicity towards non-malignant PBMC cells indicating their tumour selectivity. The compounds exhibited good in vitro anti-proliferative potency at lower concentrations against HeLa and MCF-7 cell lines and remain moderately active against SCC-40.Anees PangalYusufi MujahidBajarang DesaiJaved A. ShaikhKhursheed AhmedGrowing SciencearticleChemistryQD1-999ENCurrent Chemistry Letters, Vol 11, Iss 1, Pp 105-112 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Anees Pangal Yusufi Mujahid Bajarang Desai Javed A. Shaikh Khursheed Ahmed Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
description	Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, 1HNMR and 13CNMR. The compounds were checked for their in vitro anticancer activities against three different human cancer cell lines viz human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human oral squamous cell carcinoma (SCC-40) using SRB method. All the title compounds showed low toxicity towards non-malignant PBMC cells indicating their tumour selectivity. The compounds exhibited good in vitro anti-proliferative potency at lower concentrations against HeLa and MCF-7 cell lines and remain moderately active against SCC-40.
format	article
author	Anees Pangal Yusufi Mujahid Bajarang Desai Javed A. Shaikh Khursheed Ahmed
author_facet	Anees Pangal Yusufi Mujahid Bajarang Desai Javed A. Shaikh Khursheed Ahmed
author_sort	Anees Pangal
title	Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
title_short	Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
title_full	Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
title_fullStr	Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
title_full_unstemmed	Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
title_sort	synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2h-chromen-2-one derivatives as new anticancer agents
publisher	Growing Science
publishDate	2022
url	https://doaj.org/article/a7d048a987514ad3be380889d499943f
work_keys_str_mv	AT aneespangal synthesisof32subsitutedtrifluoromethylphenylaminoacetyl2hchromen2onederivativesasnewanticanceragents AT yusufimujahid synthesisof32subsitutedtrifluoromethylphenylaminoacetyl2hchromen2onederivativesasnewanticanceragents AT bajarangdesai synthesisof32subsitutedtrifluoromethylphenylaminoacetyl2hchromen2onederivativesasnewanticanceragents AT javedashaikh synthesisof32subsitutedtrifluoromethylphenylaminoacetyl2hchromen2onederivativesasnewanticanceragents AT khursheedahmed synthesisof32subsitutedtrifluoromethylphenylaminoacetyl2hchromen2onederivativesasnewanticanceragents
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Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents

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