High-fat diet induces apoptosis of hypothalamic neurons.

Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammator...

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Autores principales:	Juliana C Moraes, Andressa Coope, Joseane Morari, Dennys E Cintra, Erika A Roman, José R Pauli, Talita Romanatto, José B Carvalheira, Alexandre L R Oliveira, Mario J Saad, Licio A Velloso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7d0e63a092644f5bc26ec40e48366f8
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spelling	oai:doaj.org-article:a7d0e63a092644f5bc26ec40e48366f82021-11-25T06:16:20ZHigh-fat diet induces apoptosis of hypothalamic neurons.1932-620310.1371/journal.pone.0005045https://doaj.org/article/a7d0e63a092644f5bc26ec40e48366f82009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19340313/?tool=EBIhttps://doaj.org/toc/1932-6203Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammatory signal transduction can lead to the activation of apoptotic signaling pathways, we evaluated the effect of high-fat feeding on the induction of apoptosis of hypothalamic cells. Here, we show that consumption of dietary fats induce apoptosis of neurons and a reduction of synaptic inputs in the arcuate nucleus and lateral hypothalamus. This effect is dependent upon diet composition, and not on caloric intake, since pair-feeding is not sufficient to reduce the expression of apoptotic markers. The presence of an intact TLR4 receptor, protects cells from further apoptotic signals. In diet-induced inflammation of the hypothalamus, TLR4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity.Juliana C MoraesAndressa CoopeJoseane MorariDennys E CintraErika A RomanJosé R PauliTalita RomanattoJosé B CarvalheiraAlexandre L R OliveiraMario J SaadLicio A VellosoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 4, p e5045 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juliana C Moraes Andressa Coope Joseane Morari Dennys E Cintra Erika A Roman José R Pauli Talita Romanatto José B Carvalheira Alexandre L R Oliveira Mario J Saad Licio A Velloso High-fat diet induces apoptosis of hypothalamic neurons.
description	Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammatory signal transduction can lead to the activation of apoptotic signaling pathways, we evaluated the effect of high-fat feeding on the induction of apoptosis of hypothalamic cells. Here, we show that consumption of dietary fats induce apoptosis of neurons and a reduction of synaptic inputs in the arcuate nucleus and lateral hypothalamus. This effect is dependent upon diet composition, and not on caloric intake, since pair-feeding is not sufficient to reduce the expression of apoptotic markers. The presence of an intact TLR4 receptor, protects cells from further apoptotic signals. In diet-induced inflammation of the hypothalamus, TLR4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity.
format	article
author	Juliana C Moraes Andressa Coope Joseane Morari Dennys E Cintra Erika A Roman José R Pauli Talita Romanatto José B Carvalheira Alexandre L R Oliveira Mario J Saad Licio A Velloso
author_facet	Juliana C Moraes Andressa Coope Joseane Morari Dennys E Cintra Erika A Roman José R Pauli Talita Romanatto José B Carvalheira Alexandre L R Oliveira Mario J Saad Licio A Velloso
author_sort	Juliana C Moraes
title	High-fat diet induces apoptosis of hypothalamic neurons.
title_short	High-fat diet induces apoptosis of hypothalamic neurons.
title_full	High-fat diet induces apoptosis of hypothalamic neurons.
title_fullStr	High-fat diet induces apoptosis of hypothalamic neurons.
title_full_unstemmed	High-fat diet induces apoptosis of hypothalamic neurons.
title_sort	high-fat diet induces apoptosis of hypothalamic neurons.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/a7d0e63a092644f5bc26ec40e48366f8
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High-fat diet induces apoptosis of hypothalamic neurons.

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