The effect of coarctation degrees on wall shear stress indices

Abstract Coarctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta. Flow quantification can be immensely valuable for an early and accurate diagnosis. However, there is a lack of appropriate diagnostic approaches for a variety of cardiovascular diseases, such as CoA....

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Autores principales:	Deniz Rafieianzab, Mohammad Amin Abazari, M. Soltani, Mona Alimohammadi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7d56ecd04ba428cab651d7d4d0c5074
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spelling	oai:doaj.org-article:a7d56ecd04ba428cab651d7d4d0c50742021-12-02T17:22:58ZThe effect of coarctation degrees on wall shear stress indices10.1038/s41598-021-92104-32045-2322https://doaj.org/article/a7d56ecd04ba428cab651d7d4d0c50742021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92104-3https://doaj.org/toc/2045-2322Abstract Coarctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta. Flow quantification can be immensely valuable for an early and accurate diagnosis. However, there is a lack of appropriate diagnostic approaches for a variety of cardiovascular diseases, such as CoA. An accurate understanding of the disease depends on measurements of the global haemodynamics (criteria for heart function) and also the local haemodynamics (detailed data on the dynamics of blood flow). Playing a significant role in clinical processes, wall shear stress (WSS) cannot be measured clinically; thus, computation tools are needed to give an insight into this crucial haemodynamic parameter. In the present study, in order to enable the progress of non-invasive approaches that quantify global and local haemodynamics for different CoA severities, innovative computational blueprint simulations that include fluid–solid interaction models are developed. Since there is no clear approach for managing the CoA regarding its severity, this study proposes the use of WSS indices and pressure gradient to better establish a framework for treatment procedures in CoA patients with different severities. This provides a platform for improving CoA therapy on a patient-specific level, in which physicians can perform treatment methods based on WSS indices on top of using a mere experience. Results show how severe CoA affects the aorta in comparison to the milder cases, which can give the medical community valuable information before and after any intervention.Deniz RafieianzabMohammad Amin AbazariM. SoltaniMona AlimohammadiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deniz Rafieianzab Mohammad Amin Abazari M. Soltani Mona Alimohammadi The effect of coarctation degrees on wall shear stress indices
description	Abstract Coarctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta. Flow quantification can be immensely valuable for an early and accurate diagnosis. However, there is a lack of appropriate diagnostic approaches for a variety of cardiovascular diseases, such as CoA. An accurate understanding of the disease depends on measurements of the global haemodynamics (criteria for heart function) and also the local haemodynamics (detailed data on the dynamics of blood flow). Playing a significant role in clinical processes, wall shear stress (WSS) cannot be measured clinically; thus, computation tools are needed to give an insight into this crucial haemodynamic parameter. In the present study, in order to enable the progress of non-invasive approaches that quantify global and local haemodynamics for different CoA severities, innovative computational blueprint simulations that include fluid–solid interaction models are developed. Since there is no clear approach for managing the CoA regarding its severity, this study proposes the use of WSS indices and pressure gradient to better establish a framework for treatment procedures in CoA patients with different severities. This provides a platform for improving CoA therapy on a patient-specific level, in which physicians can perform treatment methods based on WSS indices on top of using a mere experience. Results show how severe CoA affects the aorta in comparison to the milder cases, which can give the medical community valuable information before and after any intervention.
format	article
author	Deniz Rafieianzab Mohammad Amin Abazari M. Soltani Mona Alimohammadi
author_facet	Deniz Rafieianzab Mohammad Amin Abazari M. Soltani Mona Alimohammadi
author_sort	Deniz Rafieianzab
title	The effect of coarctation degrees on wall shear stress indices
title_short	The effect of coarctation degrees on wall shear stress indices
title_full	The effect of coarctation degrees on wall shear stress indices
title_fullStr	The effect of coarctation degrees on wall shear stress indices
title_full_unstemmed	The effect of coarctation degrees on wall shear stress indices
title_sort	effect of coarctation degrees on wall shear stress indices
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7d56ecd04ba428cab651d7d4d0c5074
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The effect of coarctation degrees on wall shear stress indices

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