Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment

Kimihito Maeda, Yuichiro Ohara, Masato Hashimoto, Hiroshi OhguroDepartment of Ophthalmology, Sapporo Medical University, School of Medicine, Sapporo, JapanPurpose: To investigate whether serum levels of soluble Fas (sFas) and interleukin-6 (IL-6) could function as an index of the efficacy of steroid...

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Autores principales:	Kimihito Maeda, Yuichiro Ohara, Masato Hashimoto, Hiroshi Ohguro
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a7d89e6d2f924dec8dfd78f1928c5f5d
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spelling	oai:doaj.org-article:a7d89e6d2f924dec8dfd78f1928c5f5d2021-12-02T09:47:18ZAnalysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment1177-54671177-5483https://doaj.org/article/a7d89e6d2f924dec8dfd78f1928c5f5d2008-10-01T00:00:00Zhttp://www.dovepress.com/analysis-of-sfas-il-6-levels-in-thyroid-associated-ophthalmopathy-pre--a2368https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kimihito Maeda, Yuichiro Ohara, Masato Hashimoto, Hiroshi OhguroDepartment of Ophthalmology, Sapporo Medical University, School of Medicine, Sapporo, JapanPurpose: To investigate whether serum levels of soluble Fas (sFas) and interleukin-6 (IL-6) could function as an index of the efficacy of steroid pulse treatment, we examined the serum level of these proteins before and after steroid pulse treatment in thyroid-associated ophthalmopathy patients.Methods: We gathered the blood of thyroid-associated ophthalmopathy patients before or after steroid pulse treatment, obtained serum with a centrifuge, and measured the serum levels of sFas and IL-6 by enzyme-linked immunosorbent assay (ELISA).Results: There was no difference in serum IL-6 value between pre- and poststeroid pulse treatment. Serum sFas value was significantly decreased in both pre- and poststeroid pulse treatment. Furthermore, there was a recognizable improvement in the degree of the extraocular muscle thickening after treatment in cases in whom the serum sFas value was lower than 3 ng/ml prior to the beginning of the therapy. In patients who had a serum sFas value of more than 3 ng/ml, there was no improvement in the degree of thickening of the extraocular muscle.Conclusions: Serum level of sFas is an accurate index of the outcome of steroid pulse treatment in thyroid-associated ophthalmopathy and may become a useful index to gauge the status of convalescence.Keywords: sFas, IL-6, ELISA, thyroid associated ophthalmopathy, steroid pulse treatment Kimihito MaedaYuichiro OharaMasato HashimotoHiroshi OhguroDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 609-612 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kimihito Maeda Yuichiro Ohara Masato Hashimoto Hiroshi Ohguro Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
description	Kimihito Maeda, Yuichiro Ohara, Masato Hashimoto, Hiroshi OhguroDepartment of Ophthalmology, Sapporo Medical University, School of Medicine, Sapporo, JapanPurpose: To investigate whether serum levels of soluble Fas (sFas) and interleukin-6 (IL-6) could function as an index of the efficacy of steroid pulse treatment, we examined the serum level of these proteins before and after steroid pulse treatment in thyroid-associated ophthalmopathy patients.Methods: We gathered the blood of thyroid-associated ophthalmopathy patients before or after steroid pulse treatment, obtained serum with a centrifuge, and measured the serum levels of sFas and IL-6 by enzyme-linked immunosorbent assay (ELISA).Results: There was no difference in serum IL-6 value between pre- and poststeroid pulse treatment. Serum sFas value was significantly decreased in both pre- and poststeroid pulse treatment. Furthermore, there was a recognizable improvement in the degree of the extraocular muscle thickening after treatment in cases in whom the serum sFas value was lower than 3 ng/ml prior to the beginning of the therapy. In patients who had a serum sFas value of more than 3 ng/ml, there was no improvement in the degree of thickening of the extraocular muscle.Conclusions: Serum level of sFas is an accurate index of the outcome of steroid pulse treatment in thyroid-associated ophthalmopathy and may become a useful index to gauge the status of convalescence.Keywords: sFas, IL-6, ELISA, thyroid associated ophthalmopathy, steroid pulse treatment
format	article
author	Kimihito Maeda Yuichiro Ohara Masato Hashimoto Hiroshi Ohguro
author_facet	Kimihito Maeda Yuichiro Ohara Masato Hashimoto Hiroshi Ohguro
author_sort	Kimihito Maeda
title	Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
title_short	Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
title_full	Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
title_fullStr	Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
title_full_unstemmed	Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment
title_sort	analysis of sfas il-6 levels in thyroid-associated ophthalmopathy: pre- or poststeroid pulse treatment
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a7d89e6d2f924dec8dfd78f1928c5f5d
work_keys_str_mv	AT kimihitomaeda analysisofsfasil6levelsinthyroidassociatedophthalmopathypreorpoststeroidpulsetreatment AT yuichiroohara analysisofsfasil6levelsinthyroidassociatedophthalmopathypreorpoststeroidpulsetreatment AT masatohashimoto analysisofsfasil6levelsinthyroidassociatedophthalmopathypreorpoststeroidpulsetreatment AT hiroshiohguro analysisofsfasil6levelsinthyroidassociatedophthalmopathypreorpoststeroidpulsetreatment
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Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment

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