A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis

Abstract Biomolecule abundance levels change with the environment and enable a living system to adapt to the new conditions. Although, the living system maintains at least some characteristics, e.g. homeostasis. One of the characteristics maintained by a living system is a power law distribution of...

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Autores principales:	Shumpei Sato, Makoto Horikawa, Takeshi Kondo, Tomohito Sato, Mitsutoshi Setou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7e1b59175074fa797898228b9f3a1ca
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spelling	oai:doaj.org-article:a7e1b59175074fa797898228b9f3a1ca2021-12-02T15:08:01ZA power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis10.1038/s41598-018-28667-52045-2322https://doaj.org/article/a7e1b59175074fa797898228b9f3a1ca2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28667-5https://doaj.org/toc/2045-2322Abstract Biomolecule abundance levels change with the environment and enable a living system to adapt to the new conditions. Although, the living system maintains at least some characteristics, e.g. homeostasis. One of the characteristics maintained by a living system is a power law distribution of biomolecule abundance levels. Previous studies have pointed to a universal characteristic of biochemical reaction networks, with data obtained from lysates of multiple cells. As a result, the spatial scale of the data related to the power law distribution of biomolecule abundance levels is not clear. In this study, we researched the scaling law of metabolites in mouse tissue with a spatial scale of quantification that was changed stepwise between a whole-tissue section and a single-point analysis (25 μm). As a result, metabolites in mouse tissues were found to follow the power law distribution independently of the spatial scale of analysis. Additionally, we tested the temporal changes by comparing data from younger and older mice. Both followed similar power law distributions, indicating that metabolite composition is not diversified by aging to disrupt the power law distribution. The power law distribution of metabolite abundance is thus a robust characteristic of a living system regardless of time and space.Shumpei SatoMakoto HorikawaTakeshi KondoTomohito SatoMitsutoshi SetouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shumpei Sato Makoto Horikawa Takeshi Kondo Tomohito Sato Mitsutoshi Setou A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
description	Abstract Biomolecule abundance levels change with the environment and enable a living system to adapt to the new conditions. Although, the living system maintains at least some characteristics, e.g. homeostasis. One of the characteristics maintained by a living system is a power law distribution of biomolecule abundance levels. Previous studies have pointed to a universal characteristic of biochemical reaction networks, with data obtained from lysates of multiple cells. As a result, the spatial scale of the data related to the power law distribution of biomolecule abundance levels is not clear. In this study, we researched the scaling law of metabolites in mouse tissue with a spatial scale of quantification that was changed stepwise between a whole-tissue section and a single-point analysis (25 μm). As a result, metabolites in mouse tissues were found to follow the power law distribution independently of the spatial scale of analysis. Additionally, we tested the temporal changes by comparing data from younger and older mice. Both followed similar power law distributions, indicating that metabolite composition is not diversified by aging to disrupt the power law distribution. The power law distribution of metabolite abundance is thus a robust characteristic of a living system regardless of time and space.
format	article
author	Shumpei Sato Makoto Horikawa Takeshi Kondo Tomohito Sato Mitsutoshi Setou
author_facet	Shumpei Sato Makoto Horikawa Takeshi Kondo Tomohito Sato Mitsutoshi Setou
author_sort	Shumpei Sato
title	A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
title_short	A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
title_full	A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
title_fullStr	A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
title_full_unstemmed	A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
title_sort	power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a7e1b59175074fa797898228b9f3a1ca
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A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis

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