Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion

AIM: To observe the therapeutic efficacy of intravitreal injection of conbercept for macular edema in different types of retinal vein occlusion(RVO).METHODS: Retrospective cohort study of 79 patients 79 eyes in different types of RVO(BRVO:54; non-ischemic CRVO: 16; ischemic CRVO: 9)received intravit...

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Autores principales:	Peng-Yao Lin, Yan Shi, Bo Li, Yi-Meng Ruan, Shan-Shan Hua
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	retinal vein occlusion macular edema conbercept anti-vegf Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a7e72d91e60b4fc886a730847b5ebc29
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spelling	oai:doaj.org-article:a7e72d91e60b4fc886a730847b5ebc292021-11-22T14:22:33ZClinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion1672-512310.3980/j.issn.1672-5123.2021.12.24https://doaj.org/article/a7e72d91e60b4fc886a730847b5ebc292021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112024.pdfhttps://doaj.org/toc/1672-5123AIM: To observe the therapeutic efficacy of intravitreal injection of conbercept for macular edema in different types of retinal vein occlusion(RVO).METHODS: Retrospective cohort study of 79 patients 79 eyes in different types of RVO(BRVO:54; non-ischemic CRVO: 16; ischemic CRVO: 9)received intravitreal injection of conbercept. After 3mo injection of conbercept(IVIC), a pro re nata(PRN)strategy was adopted. The best-corrected visual acuity(BCVA,LogMAR)and central macular thickness(CMT)were recorded at baseline and at 1d, 1, 2, 3, 4, 5, 6mo post-treatment.RESULTS: At 6mo, in different types of RVO, the BCVA were improved significantly than baseline(0.22±0.23 vs 0.70±0.32; 0.24±0.19 vs 0.73±0.27; 1.20±0.37 vs 1.92±0.23; all P<0.05). CMT were decreased significantly than baseline(199±27 vs 422±162μm; 195±16 vs 550±158μm; 231±55 vs 583±152μm; all P<0.05). In three different treatment time groups, CMT in different types of RVO were decresed than the baselineat different time points after treatment(P<0.05), and there was no difference between groups(P>0.05). In three different treatment time groups, BCVA in BRVO and non-iCRVO were improved than the baseline in three groups(P<0.05), but in iCRVO there were little improved in >90d group.CONCLUSION: Intravitreal injection of conbercept can effectively treat macular edema caused by RVO. Early and timely treatment of anti-VEGF may help improve and maintain the stability of long-term vision, and delayed anti-VEGF treatment may reduce the space for the improving vision.Peng-Yao LinYan ShiBo LiYi-Meng RuanShan-Shan HuaPress of International Journal of Ophthalmology (IJO PRESS)articleretinal vein occlusionmacular edemaconberceptanti-vegfOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2145-2149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal vein occlusion macular edema conbercept anti-vegf Ophthalmology RE1-994
spellingShingle	retinal vein occlusion macular edema conbercept anti-vegf Ophthalmology RE1-994 Peng-Yao Lin Yan Shi Bo Li Yi-Meng Ruan Shan-Shan Hua Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
description	AIM: To observe the therapeutic efficacy of intravitreal injection of conbercept for macular edema in different types of retinal vein occlusion(RVO).METHODS: Retrospective cohort study of 79 patients 79 eyes in different types of RVO(BRVO:54; non-ischemic CRVO: 16; ischemic CRVO: 9)received intravitreal injection of conbercept. After 3mo injection of conbercept(IVIC), a pro re nata(PRN)strategy was adopted. The best-corrected visual acuity(BCVA,LogMAR)and central macular thickness(CMT)were recorded at baseline and at 1d, 1, 2, 3, 4, 5, 6mo post-treatment.RESULTS: At 6mo, in different types of RVO, the BCVA were improved significantly than baseline(0.22±0.23 vs 0.70±0.32; 0.24±0.19 vs 0.73±0.27; 1.20±0.37 vs 1.92±0.23; all P<0.05). CMT were decreased significantly than baseline(199±27 vs 422±162μm; 195±16 vs 550±158μm; 231±55 vs 583±152μm; all P<0.05). In three different treatment time groups, CMT in different types of RVO were decresed than the baselineat different time points after treatment(P<0.05), and there was no difference between groups(P>0.05). In three different treatment time groups, BCVA in BRVO and non-iCRVO were improved than the baseline in three groups(P<0.05), but in iCRVO there were little improved in >90d group.CONCLUSION: Intravitreal injection of conbercept can effectively treat macular edema caused by RVO. Early and timely treatment of anti-VEGF may help improve and maintain the stability of long-term vision, and delayed anti-VEGF treatment may reduce the space for the improving vision.
format	article
author	Peng-Yao Lin Yan Shi Bo Li Yi-Meng Ruan Shan-Shan Hua
author_facet	Peng-Yao Lin Yan Shi Bo Li Yi-Meng Ruan Shan-Shan Hua
author_sort	Peng-Yao Lin
title	Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
title_short	Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
title_full	Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
title_fullStr	Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
title_full_unstemmed	Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion
title_sort	clinical therapeutic effects of intravitreal injection of conbercept for macular edema in different types of retinal vein occlusion
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/a7e72d91e60b4fc886a730847b5ebc29
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Clinical therapeutic effects of intravitreal injection of Conbercept for macular edema in different types of retinal vein occlusion

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