Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression

Gülfizar Sözeri-Varma,1 Nalan Kalkan-Oğuzhanoglu,1 Muharrem Efe,1 Yilmaz Kiroglu,2 Taçlan Duman11Department of Psychiatry, 2Department of Radiology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyBackground: Previous studies have determined the neurochemical m...

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Autores principales:	Sozeri-Varma G, Kalkan-Oguzhanoglu N, Efe M, Kiroglu Y, Duman T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a7ea4b5ef59340c8bdeb4cc674ff760c
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spelling	oai:doaj.org-article:a7ea4b5ef59340c8bdeb4cc674ff760c2021-12-02T02:57:40ZNeurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression1176-63281178-2021https://doaj.org/article/a7ea4b5ef59340c8bdeb4cc674ff760c2013-08-01T00:00:00Zhttp://www.dovepress.com/neurochemical-metabolites-in-prefrontal-cortex-in-patients-with-mildmo-a13993https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Gülfizar Sözeri-Varma,1 Nalan Kalkan-Oğuzhanoglu,1 Muharrem Efe,1 Yilmaz Kiroglu,2 Taçlan Duman11Department of Psychiatry, 2Department of Radiology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyBackground: Previous studies have determined the neurochemical metabolite abnormalities in major depressive disorder (MDD). The results of studies are inconsistent. Severity of depression may relate to neurochemical metabolic changes. The aim of this study is to investigate neurochemical metabolite levels in the prefrontal cortex (PFC) of patients with mild/moderate MDD.Methods: Twenty-one patients with mild MDD, 18 patients with moderate MDD, and 16 matched control subjects participated in the study. Patients had had their first episode. They had not taken treatment. The severity of depression was assessed by the Hamilton Rating Scale for Depression (HAM-D). Levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho), and creatine-containing compounds (Cr) were measured using proton magnetic resonance spectroscopy (1H-MRS) at 1.5 T, with an 8-cm3 single voxel placed in the right PFC.Results: The moderate MDD patients had lower NAA/Cr levels than the control group. No differences were found in neurochemical metabolite levels between the mild MDD and control groups. No correlation was found between the patients’ neurochemical metabolite levels and HAM-D scores.Conclusion: Our findings suggest that NAA/Cr levels are low in moderate-level MDD in the PFC. Neurochemical metabolite levels did not change in mild depressive disorder. Our results suggest that the severity of depression may affect neuronal function and viability. Studies are needed to confirm this finding, including studies on severely depressive patients.Keywords: major depressive disorder, magnetic resonance spectroscopy, N-acetyl aspartate, creatine, cholineSozeri-Varma GKalkan-Oguzhanoglu NEfe MKiroglu YDuman TDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1053-1059 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sozeri-Varma G Kalkan-Oguzhanoglu N Efe M Kiroglu Y Duman T Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
description	Gülfizar Sözeri-Varma,1 Nalan Kalkan-Oğuzhanoglu,1 Muharrem Efe,1 Yilmaz Kiroglu,2 Taçlan Duman11Department of Psychiatry, 2Department of Radiology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyBackground: Previous studies have determined the neurochemical metabolite abnormalities in major depressive disorder (MDD). The results of studies are inconsistent. Severity of depression may relate to neurochemical metabolic changes. The aim of this study is to investigate neurochemical metabolite levels in the prefrontal cortex (PFC) of patients with mild/moderate MDD.Methods: Twenty-one patients with mild MDD, 18 patients with moderate MDD, and 16 matched control subjects participated in the study. Patients had had their first episode. They had not taken treatment. The severity of depression was assessed by the Hamilton Rating Scale for Depression (HAM-D). Levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho), and creatine-containing compounds (Cr) were measured using proton magnetic resonance spectroscopy (1H-MRS) at 1.5 T, with an 8-cm3 single voxel placed in the right PFC.Results: The moderate MDD patients had lower NAA/Cr levels than the control group. No differences were found in neurochemical metabolite levels between the mild MDD and control groups. No correlation was found between the patients’ neurochemical metabolite levels and HAM-D scores.Conclusion: Our findings suggest that NAA/Cr levels are low in moderate-level MDD in the PFC. Neurochemical metabolite levels did not change in mild depressive disorder. Our results suggest that the severity of depression may affect neuronal function and viability. Studies are needed to confirm this finding, including studies on severely depressive patients.Keywords: major depressive disorder, magnetic resonance spectroscopy, N-acetyl aspartate, creatine, choline
format	article
author	Sozeri-Varma G Kalkan-Oguzhanoglu N Efe M Kiroglu Y Duman T
author_facet	Sozeri-Varma G Kalkan-Oguzhanoglu N Efe M Kiroglu Y Duman T
author_sort	Sozeri-Varma G
title	Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
title_short	Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
title_full	Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
title_fullStr	Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
title_full_unstemmed	Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
title_sort	neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a7ea4b5ef59340c8bdeb4cc674ff760c
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Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression

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