Metabolism

The awareness that exercise is an essential means to maintain an adequate response to health challenges is increasing worldwide. Although whole body metabolism is governed by many organs that communicate to ascertain metabolic homeostasis, especially skeletal muscle is central in the response to met...

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Autores principales:	Giacco A, delli Paoli G, Lanni A, de Lange P
Formato:	article
Lenguaje:	DE EN
Publicado:	Dynamic Media Sales Verlag 2019
Materias:	Sports medicine RC1200-1245
Acceso en línea:	https://doaj.org/article/a7eb76aad4a746fca87bb64cb7ef2feb
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id	oai:doaj.org-article:a7eb76aad4a746fca87bb64cb7ef2feb
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spelling	oai:doaj.org-article:a7eb76aad4a746fca87bb64cb7ef2feb2021-11-16T19:01:41ZMetabolism0344-59252510-526410.5960/dzsm.2019.364https://doaj.org/article/a7eb76aad4a746fca87bb64cb7ef2feb2019-04-01T00:00:00Zhttps://www.germanjournalsportsmedicine.com/archiv/archiv-2019/issue-4/exercise-and-metabolic-health/https://doaj.org/toc/0344-5925https://doaj.org/toc/2510-5264The awareness that exercise is an essential means to maintain an adequate response to health challenges is increasing worldwide. Although whole body metabolism is governed by many organs that communicate to ascertain metabolic homeostasis, especially skeletal muscle is central in the response to metabolic changes, since it is the major site of glucose uptake and usage. Thus, metabolic diseases related to poor lipid/glucose handling due to over-nutrition and insufficient physical activity often trace back to muscle metabolic dysfunction, and vice versa. There is evidence that local thyroid hormone levels in muscle are crucial for the response to exercise, and that metabolically-active thyroid hormones can be considered possible exercise mimetics.Based on data obtained in rodents as well as humans, this short review aims to shedto light on why muscle metabolic integrity in response to exercise (increasingly studied in combination with restricted nutrition) is crucial for health, rangingfrom mechanistic aspects of muscle metabolism to the application of exercise to counteract dysfunction of metabolically-active tissues including liver and muscle itself. KEY WORDS: Exercise, Fasting, Insulin Resistance, Lipid MetabolismGiacco Adelli Paoli GLanni Ade Lange PDynamic Media Sales VerlagarticleSports medicineRC1200-1245DEENDeutsche Zeitschrift für Sportmedizin, Vol 70, Iss 4 (2019)
institution	DOAJ
collection	DOAJ
language	DE EN
topic	Sports medicine RC1200-1245
spellingShingle	Sports medicine RC1200-1245 Giacco A delli Paoli G Lanni A de Lange P Metabolism
description	The awareness that exercise is an essential means to maintain an adequate response to health challenges is increasing worldwide. Although whole body metabolism is governed by many organs that communicate to ascertain metabolic homeostasis, especially skeletal muscle is central in the response to metabolic changes, since it is the major site of glucose uptake and usage. Thus, metabolic diseases related to poor lipid/glucose handling due to over-nutrition and insufficient physical activity often trace back to muscle metabolic dysfunction, and vice versa. There is evidence that local thyroid hormone levels in muscle are crucial for the response to exercise, and that metabolically-active thyroid hormones can be considered possible exercise mimetics.Based on data obtained in rodents as well as humans, this short review aims to shedto light on why muscle metabolic integrity in response to exercise (increasingly studied in combination with restricted nutrition) is crucial for health, rangingfrom mechanistic aspects of muscle metabolism to the application of exercise to counteract dysfunction of metabolically-active tissues including liver and muscle itself. KEY WORDS: Exercise, Fasting, Insulin Resistance, Lipid Metabolism
format	article
author	Giacco A delli Paoli G Lanni A de Lange P
author_facet	Giacco A delli Paoli G Lanni A de Lange P
author_sort	Giacco A
title	Metabolism
title_short	Metabolism
title_full	Metabolism
title_fullStr	Metabolism
title_full_unstemmed	Metabolism
title_sort	metabolism
publisher	Dynamic Media Sales Verlag
publishDate	2019
url	https://doaj.org/article/a7eb76aad4a746fca87bb64cb7ef2feb
work_keys_str_mv	AT giaccoa metabolism AT dellipaolig metabolism AT lannia metabolism AT delangep metabolism
_version_	1718426194842484736

Metabolism

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