Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

Abstract Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported to reduce the symptoms of HE, but l...

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Autores principales:	Emmanuelle Flatt, Valérie A. McLin, Olivier Braissant, Katarzyna Pierzchala, Paola Mastromarino, Stefanita-Octavian Mitrea, Dario Sessa, Rolf Gruetter, Cristina Cudalbu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7ef8e8b4f0c43e88d7e80c9cb740c5a
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spelling	oai:doaj.org-article:a7ef8e8b4f0c43e88d7e80c9cb740c5a2021-12-02T17:19:15ZProbiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE10.1038/s41598-021-97018-82045-2322https://doaj.org/article/a7ef8e8b4f0c43e88d7e80c9cb740c5a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97018-8https://doaj.org/toc/2045-2322Abstract Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported to reduce the symptoms of HE, but longitudinal studies assessing their effects on brain metabolism are lacking and the molecular mechanisms underpinning their effects are not fully understood. Therefore, we evaluated in detail the effects of these different treatments on the neurometabolic changes associated with type C HE using a multimodal approach including ultra-high field in vivo 1H MRS. We analyzed longitudinally the effect of rifaximin alone or in combination with the probiotic Vivomixx on the brain metabolic profile in the hippocampus and cerebellum of bile duct ligated (BDL) rats, an established model of type C HE. Overall, while rifaximin alone appeared to induce no significant effect on the neurometabolic profile of BDL rats, its association with the probiotic resulted in more attenuated neurometabolic alterations in BDL rats followed longitudinally (i.e. a smaller increase in Gln and milder decrease in Glu and Cr levels). Given that both rifaximin and some probiotics are used in the treatment of HE, the implications of these findings may be clinically relevant.Emmanuelle FlattValérie A. McLinOlivier BraissantKatarzyna PierzchalaPaola MastromarinoStefanita-Octavian MitreaDario SessaRolf GruetterCristina CudalbuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanuelle Flatt Valérie A. McLin Olivier Braissant Katarzyna Pierzchala Paola Mastromarino Stefanita-Octavian Mitrea Dario Sessa Rolf Gruetter Cristina Cudalbu Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
description	Abstract Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported to reduce the symptoms of HE, but longitudinal studies assessing their effects on brain metabolism are lacking and the molecular mechanisms underpinning their effects are not fully understood. Therefore, we evaluated in detail the effects of these different treatments on the neurometabolic changes associated with type C HE using a multimodal approach including ultra-high field in vivo 1H MRS. We analyzed longitudinally the effect of rifaximin alone or in combination with the probiotic Vivomixx on the brain metabolic profile in the hippocampus and cerebellum of bile duct ligated (BDL) rats, an established model of type C HE. Overall, while rifaximin alone appeared to induce no significant effect on the neurometabolic profile of BDL rats, its association with the probiotic resulted in more attenuated neurometabolic alterations in BDL rats followed longitudinally (i.e. a smaller increase in Gln and milder decrease in Glu and Cr levels). Given that both rifaximin and some probiotics are used in the treatment of HE, the implications of these findings may be clinically relevant.
format	article
author	Emmanuelle Flatt Valérie A. McLin Olivier Braissant Katarzyna Pierzchala Paola Mastromarino Stefanita-Octavian Mitrea Dario Sessa Rolf Gruetter Cristina Cudalbu
author_facet	Emmanuelle Flatt Valérie A. McLin Olivier Braissant Katarzyna Pierzchala Paola Mastromarino Stefanita-Octavian Mitrea Dario Sessa Rolf Gruetter Cristina Cudalbu
author_sort	Emmanuelle Flatt
title	Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
title_short	Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
title_full	Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
title_fullStr	Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
title_full_unstemmed	Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
title_sort	probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type c he
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7ef8e8b4f0c43e88d7e80c9cb740c5a
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Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

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