A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.

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Autores principales: Yuanyuan Shi, Xiaoqing Hu, Jin Cheng, Xin Zhang, Fengyuan Zhao, Weili Shi, Bo Ren, Huilei Yu, Peng Yang, Zong Li, Qiang Liu, Zhenlong Liu, Xiaoning Duan, Xin Fu, Jiying Zhang, Jianquan Wang, Yingfang Ao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a7efca7978f544758c5cefbd8525834b
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spelling oai:doaj.org-article:a7efca7978f544758c5cefbd8525834b2021-12-02T15:35:32ZA small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development10.1038/s41467-019-09839-x2041-1723https://doaj.org/article/a7efca7978f544758c5cefbd8525834b2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09839-xhttps://doaj.org/toc/2041-1723Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.Yuanyuan ShiXiaoqing HuJin ChengXin ZhangFengyuan ZhaoWeili ShiBo RenHuilei YuPeng YangZong LiQiang LiuZhenlong LiuXiaoning DuanXin FuJiying ZhangJianquan WangYingfang AoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuanyuan Shi
Xiaoqing Hu
Jin Cheng
Xin Zhang
Fengyuan Zhao
Weili Shi
Bo Ren
Huilei Yu
Peng Yang
Zong Li
Qiang Liu
Zhenlong Liu
Xiaoning Duan
Xin Fu
Jiying Zhang
Jianquan Wang
Yingfang Ao
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
description Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.
format article
author Yuanyuan Shi
Xiaoqing Hu
Jin Cheng
Xin Zhang
Fengyuan Zhao
Weili Shi
Bo Ren
Huilei Yu
Peng Yang
Zong Li
Qiang Liu
Zhenlong Liu
Xiaoning Duan
Xin Fu
Jiying Zhang
Jianquan Wang
Yingfang Ao
author_facet Yuanyuan Shi
Xiaoqing Hu
Jin Cheng
Xin Zhang
Fengyuan Zhao
Weili Shi
Bo Ren
Huilei Yu
Peng Yang
Zong Li
Qiang Liu
Zhenlong Liu
Xiaoning Duan
Xin Fu
Jiying Zhang
Jianquan Wang
Yingfang Ao
author_sort Yuanyuan Shi
title A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
title_short A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
title_full A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
title_fullStr A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
title_full_unstemmed A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
title_sort small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a7efca7978f544758c5cefbd8525834b
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