Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage

Background and Purpose: Chronic obstructive pulmonary disease (COPD) has been associated with several complications and mortality in acutely ill patients. For patients with aneurysmal subarachnoid hemorrhage (aSAH), the association between COPD and clinical outcomes remains unclear.Methods: In this...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lan Yang, Yu Zhang, Wei Yao, Fang Fang, Weimin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	intracranial aneurysm chronic obstructive pulmonary disease subarachnoid hemorrhage risk factor prognosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a7f2ff9101f34b90b2195eea605d4f6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a7f2ff9101f34b90b2195eea605d4f6e
record_format	dspace
spelling	oai:doaj.org-article:a7f2ff9101f34b90b2195eea605d4f6e2021-11-15T14:09:01ZImpact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage1664-229510.3389/fneur.2021.723115https://doaj.org/article/a7f2ff9101f34b90b2195eea605d4f6e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.723115/fullhttps://doaj.org/toc/1664-2295Background and Purpose: Chronic obstructive pulmonary disease (COPD) has been associated with several complications and mortality in acutely ill patients. For patients with aneurysmal subarachnoid hemorrhage (aSAH), the association between COPD and clinical outcomes remains unclear.Methods: In this retrospective cohort study, we analyzed consecutive aSAH patients admitted to the West China Hospital between 2014 and 2019. Propensity score matching analysis and cox regression models was used to assess the association between COPD and mortality. The primary outcome was long-term mortality.Results: Using a clinical database from a large university medical center, 2,925 patients with aSAH were identified, of whom 219 (7.5%) also had COPD. Patients were followed-up for a median of 3.8 years, and during follow-up 633 patients (21.6%) died. Long-term mortality was higher in patients with COPD compared to patients without COPD in the Cox regression models [adjusted hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.14–2.02]. Propensity score matching analysis also showed similar associations between COPD and mortality in hospital, at 1 year, at 2 years, and at long-term. Similarly, patients with COPD had significantly higher incidence of infections, such as pneumonia [odds ratio (OR) 3.24, 95% CI 2.30–4.56], urinary tract infection (OR 1.81, 95% CI 1.20–2.73), bloodstream infection (OR 3.83, 95% CI 1.84–7.99), and hospital infection (OR 3.24, 95% CI 2.28–4.61).Conclusions: Among aSAH patients, COPD is associated with increased mortality. COPD represents a significant risk factor for infections. Given that these are preventable complications, our findings are of clinical relevance.Lan YangYu ZhangYu ZhangWei YaoFang FangWeimin LiFrontiers Media S.A.articleintracranial aneurysmchronic obstructive pulmonary diseasesubarachnoid hemorrhagerisk factorprognosisNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intracranial aneurysm chronic obstructive pulmonary disease subarachnoid hemorrhage risk factor prognosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	intracranial aneurysm chronic obstructive pulmonary disease subarachnoid hemorrhage risk factor prognosis Neurology. Diseases of the nervous system RC346-429 Lan Yang Yu Zhang Yu Zhang Wei Yao Fang Fang Weimin Li Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
description	Background and Purpose: Chronic obstructive pulmonary disease (COPD) has been associated with several complications and mortality in acutely ill patients. For patients with aneurysmal subarachnoid hemorrhage (aSAH), the association between COPD and clinical outcomes remains unclear.Methods: In this retrospective cohort study, we analyzed consecutive aSAH patients admitted to the West China Hospital between 2014 and 2019. Propensity score matching analysis and cox regression models was used to assess the association between COPD and mortality. The primary outcome was long-term mortality.Results: Using a clinical database from a large university medical center, 2,925 patients with aSAH were identified, of whom 219 (7.5%) also had COPD. Patients were followed-up for a median of 3.8 years, and during follow-up 633 patients (21.6%) died. Long-term mortality was higher in patients with COPD compared to patients without COPD in the Cox regression models [adjusted hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.14–2.02]. Propensity score matching analysis also showed similar associations between COPD and mortality in hospital, at 1 year, at 2 years, and at long-term. Similarly, patients with COPD had significantly higher incidence of infections, such as pneumonia [odds ratio (OR) 3.24, 95% CI 2.30–4.56], urinary tract infection (OR 1.81, 95% CI 1.20–2.73), bloodstream infection (OR 3.83, 95% CI 1.84–7.99), and hospital infection (OR 3.24, 95% CI 2.28–4.61).Conclusions: Among aSAH patients, COPD is associated with increased mortality. COPD represents a significant risk factor for infections. Given that these are preventable complications, our findings are of clinical relevance.
format	article
author	Lan Yang Yu Zhang Yu Zhang Wei Yao Fang Fang Weimin Li
author_facet	Lan Yang Yu Zhang Yu Zhang Wei Yao Fang Fang Weimin Li
author_sort	Lan Yang
title	Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
title_short	Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
title_full	Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
title_fullStr	Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
title_full_unstemmed	Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage
title_sort	impact of chronic obstructive pulmonary disease on infectious complications and mortality in patients with aneurysmal subarachnoid hemorrhage
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a7f2ff9101f34b90b2195eea605d4f6e
work_keys_str_mv	AT lanyang impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage AT yuzhang impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage AT yuzhang impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage AT weiyao impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage AT fangfang impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage AT weiminli impactofchronicobstructivepulmonarydiseaseoninfectiouscomplicationsandmortalityinpatientswithaneurysmalsubarachnoidhemorrhage
_version_	1718428394465525760

Impact of Chronic Obstructive Pulmonary Disease on Infectious Complications and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage

Ejemplares similares