Pathogenetic features of chronic osteomyelitis treatment

Abstract Over the past decades, there has been a steady increase in the incidence of osteomyelitis. It is associated with an increased use of implants in traumatology and orthopedics. The social aspects of osteomyelitis are, on the one hand, significant financial costs for the healthcare system, an...

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Autores principales:	Denis V. Rimashevskiy, Ildar F. Akhtiamov, Pavel N. Fedulichev, Wessam Zaalan, Kamil' A. Ustazov, Abdul Basith, Jumakhan M. Moldakulov, Maxim P. Zinoviev
Formato:	article
Lenguaje:	EN RU
Publicado:	Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics 2021
Materias:	osteomyelitis periprosthetic infection biofilm etiology pathogenesis staphylococcus Orthopedic surgery RD701-811
Acceso en línea:	https://doaj.org/article/a7f4642f8da840c9af4b7ff7fd97a54e
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spelling	oai:doaj.org-article:a7f4642f8da840c9af4b7ff7fd97a54e2021-11-15T10:38:23ZPathogenetic features of chronic osteomyelitis treatment10.18019/1028-4427-2021-27-5-628-6351028-44272542-131Xhttps://doaj.org/article/a7f4642f8da840c9af4b7ff7fd97a54e2021-10-01T00:00:00Zhttps://doaj.org/toc/1028-4427https://doaj.org/toc/2542-131XAbstract Over the past decades, there has been a steady increase in the incidence of osteomyelitis. It is associated with an increased use of implants in traumatology and orthopedics. The social aspects of osteomyelitis are, on the one hand, significant financial costs for the healthcare system, and on the other hand, high recurrence and re-infection in the treatment of joint pathology associated with long-term loss of work ability and a high risk of patient’s disability. Purpose To conduct a search and analysis of publications in Russian and English, devoted to the problem of osteomyelitis and periprosthetic infection, on the basis of which to summarize the main current notions about the etiology, pathogenesis, diagnosis and treatment of osteomyelitis. Materials and methods The search was carried out in the Pubmed and CyberLeninka databases of literature sources over the past 10 years. The data were analyzed and compared with the materials from earlier publications. Only publications from peer-reviewed journals were considered for analysis. Results and discussion Success in the treatment of peri-implant infection with prosthesis re-implantation and satisfactory joint function has been achieved in only just more than a half of patients. Recent studies have significantly changed the understanding of the etiology and pathogenesis of osteomyelitis. It has been proven that in osteomyelitis and implant-associated infection, four reservoirs of infection are formed in the patient's body: abscesses in soft tissues and bone marrow canal, biofilms on the surface of implants and necrotic tissues, intracellular colonization with bacteria of the macroorganism and lacunar-canalicular system. Understanding the mechanisms of osteomyelitis development and its course forces the specialists to take a fresh look at the causes of failures in the fight against such a severe pathology and change approaches to its prevention, diagnosis and treatment.Denis V. RimashevskiyIldar F. AkhtiamovPavel N. FedulichevWessam ZaalanKamil' A. UstazovAbdul BasithJumakhan M. MoldakulovMaxim P. ZinovievRussian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedicsarticleosteomyelitisperiprosthetic infectionbiofilmetiologypathogenesisstaphylococcusOrthopedic surgeryRD701-811ENRUГений oртопедии, Vol 27, Iss 5, Pp 628-635 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	osteomyelitis periprosthetic infection biofilm etiology pathogenesis staphylococcus Orthopedic surgery RD701-811
spellingShingle	osteomyelitis periprosthetic infection biofilm etiology pathogenesis staphylococcus Orthopedic surgery RD701-811 Denis V. Rimashevskiy Ildar F. Akhtiamov Pavel N. Fedulichev Wessam Zaalan Kamil' A. Ustazov Abdul Basith Jumakhan M. Moldakulov Maxim P. Zinoviev Pathogenetic features of chronic osteomyelitis treatment
description	Abstract Over the past decades, there has been a steady increase in the incidence of osteomyelitis. It is associated with an increased use of implants in traumatology and orthopedics. The social aspects of osteomyelitis are, on the one hand, significant financial costs for the healthcare system, and on the other hand, high recurrence and re-infection in the treatment of joint pathology associated with long-term loss of work ability and a high risk of patient’s disability. Purpose To conduct a search and analysis of publications in Russian and English, devoted to the problem of osteomyelitis and periprosthetic infection, on the basis of which to summarize the main current notions about the etiology, pathogenesis, diagnosis and treatment of osteomyelitis. Materials and methods The search was carried out in the Pubmed and CyberLeninka databases of literature sources over the past 10 years. The data were analyzed and compared with the materials from earlier publications. Only publications from peer-reviewed journals were considered for analysis. Results and discussion Success in the treatment of peri-implant infection with prosthesis re-implantation and satisfactory joint function has been achieved in only just more than a half of patients. Recent studies have significantly changed the understanding of the etiology and pathogenesis of osteomyelitis. It has been proven that in osteomyelitis and implant-associated infection, four reservoirs of infection are formed in the patient's body: abscesses in soft tissues and bone marrow canal, biofilms on the surface of implants and necrotic tissues, intracellular colonization with bacteria of the macroorganism and lacunar-canalicular system. Understanding the mechanisms of osteomyelitis development and its course forces the specialists to take a fresh look at the causes of failures in the fight against such a severe pathology and change approaches to its prevention, diagnosis and treatment.
format	article
author	Denis V. Rimashevskiy Ildar F. Akhtiamov Pavel N. Fedulichev Wessam Zaalan Kamil' A. Ustazov Abdul Basith Jumakhan M. Moldakulov Maxim P. Zinoviev
author_facet	Denis V. Rimashevskiy Ildar F. Akhtiamov Pavel N. Fedulichev Wessam Zaalan Kamil' A. Ustazov Abdul Basith Jumakhan M. Moldakulov Maxim P. Zinoviev
author_sort	Denis V. Rimashevskiy
title	Pathogenetic features of chronic osteomyelitis treatment
title_short	Pathogenetic features of chronic osteomyelitis treatment
title_full	Pathogenetic features of chronic osteomyelitis treatment
title_fullStr	Pathogenetic features of chronic osteomyelitis treatment
title_full_unstemmed	Pathogenetic features of chronic osteomyelitis treatment
title_sort	pathogenetic features of chronic osteomyelitis treatment
publisher	Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
publishDate	2021
url	https://doaj.org/article/a7f4642f8da840c9af4b7ff7fd97a54e
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_version_	1718428452373135360

Pathogenetic features of chronic osteomyelitis treatment

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