Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice

Abstract Classical eyeblink conditioning is an experimental model widely used for the study of the neuronal mechanisms underlying the acquisition of new motor and cognitive skills. There are two principal interpretations of the role of the cerebellum in the learning of eyelid conditioned responses (...

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Autores principales:	Juan C. López-Ramos, Zbynek Houdek, Jan Cendelín, Frantisek Vožeh, José M. Delgado-García
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7f5b2b25ef543b6af0f5ea2f15151b4
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spelling	oai:doaj.org-article:a7f5b2b25ef543b6af0f5ea2f15151b42021-12-02T16:08:25ZTiming correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice10.1038/s41598-018-29000-w2045-2322https://doaj.org/article/a7f5b2b25ef543b6af0f5ea2f15151b42018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29000-whttps://doaj.org/toc/2045-2322Abstract Classical eyeblink conditioning is an experimental model widely used for the study of the neuronal mechanisms underlying the acquisition of new motor and cognitive skills. There are two principal interpretations of the role of the cerebellum in the learning of eyelid conditioned responses (CRs). One considers that the cerebellum is the place where this learning is acquired and stored, while the second suggests that the cerebellum is mostly involved in the proper performance of acquired CRs, implying that there must be other brain areas involved in the learning process. We checked the timing of cerebellar interpositus nucleus (IPN) neurons’ firing rate with eyelid CRs in both wild-type (WT) and Lurcher (a model of cerebellar cortex degeneration) mice. We used delay and trace conditioning paradigms. WT mice presented a better execution for delay vs. trace conditioning and also for these two paradigms than did Lurcher mice. IPN neurons were activated during CRs following the activation of the orbicularis oculi muscle. Firing patterns of IPN neurons were altered in Lurcher mice. In conclusion, the cerebellum seems to be mostly related with the performance of conditioned responses, rather than with their acquisition.Juan C. López-RamosZbynek HoudekJan CendelínFrantisek VožehJosé M. Delgado-GarcíaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan C. López-Ramos Zbynek Houdek Jan Cendelín Frantisek Vožeh José M. Delgado-García Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
description	Abstract Classical eyeblink conditioning is an experimental model widely used for the study of the neuronal mechanisms underlying the acquisition of new motor and cognitive skills. There are two principal interpretations of the role of the cerebellum in the learning of eyelid conditioned responses (CRs). One considers that the cerebellum is the place where this learning is acquired and stored, while the second suggests that the cerebellum is mostly involved in the proper performance of acquired CRs, implying that there must be other brain areas involved in the learning process. We checked the timing of cerebellar interpositus nucleus (IPN) neurons’ firing rate with eyelid CRs in both wild-type (WT) and Lurcher (a model of cerebellar cortex degeneration) mice. We used delay and trace conditioning paradigms. WT mice presented a better execution for delay vs. trace conditioning and also for these two paradigms than did Lurcher mice. IPN neurons were activated during CRs following the activation of the orbicularis oculi muscle. Firing patterns of IPN neurons were altered in Lurcher mice. In conclusion, the cerebellum seems to be mostly related with the performance of conditioned responses, rather than with their acquisition.
format	article
author	Juan C. López-Ramos Zbynek Houdek Jan Cendelín Frantisek Vožeh José M. Delgado-García
author_facet	Juan C. López-Ramos Zbynek Houdek Jan Cendelín Frantisek Vožeh José M. Delgado-García
author_sort	Juan C. López-Ramos
title	Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
title_short	Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
title_full	Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
title_fullStr	Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
title_full_unstemmed	Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice
title_sort	timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and lurcher mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a7f5b2b25ef543b6af0f5ea2f15151b4
work_keys_str_mv	AT juanclopezramos timingcorrelationsbetweencerebellarinterpositusneuronalfiringandclassicallyconditionedeyelidresponsesinwildtypeandlurchermice AT zbynekhoudek timingcorrelationsbetweencerebellarinterpositusneuronalfiringandclassicallyconditionedeyelidresponsesinwildtypeandlurchermice AT jancendelin timingcorrelationsbetweencerebellarinterpositusneuronalfiringandclassicallyconditionedeyelidresponsesinwildtypeandlurchermice AT frantisekvozeh timingcorrelationsbetweencerebellarinterpositusneuronalfiringandclassicallyconditionedeyelidresponsesinwildtypeandlurchermice AT josemdelgadogarcia timingcorrelationsbetweencerebellarinterpositusneuronalfiringandclassicallyconditionedeyelidresponsesinwildtypeandlurchermice
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Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice

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