Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples

Abstract Layered molybdenum diselenide (MoSe2) nanosheets were formed by the weak Van der Waals forces of attraction between Se and Mo atoms. MoSe2 has a larger space between the adjacent layers and smaller band gaps in the range of 0.85 to ~ 1.6 eV. In this study, MoSe2 nanosheets decorated nickel...

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Autores principales:	Gayathri Jeevanandham, Kumaran Vediappan, Zeid A. ALOthman, Tariq Altalhi, Ashok K. Sundramoorthy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7f6e0c9bba44e82be20f2cdba62f548
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spelling	oai:doaj.org-article:a7f6e0c9bba44e82be20f2cdba62f5482021-12-02T17:45:17ZFabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples10.1038/s41598-021-92620-22045-2322https://doaj.org/article/a7f6e0c9bba44e82be20f2cdba62f5482021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92620-2https://doaj.org/toc/2045-2322Abstract Layered molybdenum diselenide (MoSe2) nanosheets were formed by the weak Van der Waals forces of attraction between Se and Mo atoms. MoSe2 has a larger space between the adjacent layers and smaller band gaps in the range of 0.85 to ~ 1.6 eV. In this study, MoSe2 nanosheets decorated nickel oxide (NiO) nanorods have been synthesized by hydrothermal method using sodium molybdate and selenium metal powder. NiO/MoSe2 composite formation was confirmed by powder X-ray diffraction analysis. In addition, the presence of MoSe2 nanosheets on NiO nanorods were confirmed by field emission scanning electron microscopy, high-resolution transmission electron microscopy and X-ray photoelectron spectroscopy. The Nyquist plots of NiO/MoSe2 coated glassy carbon electrode (GCE) was indicated that it had lower charge transfer resistance compared to NiO/GCE and MoSe2/GCE. Furthermore, as-prepared NiO/MoSe2/GCE was used to detect glucose in alkaline solution by cyclic voltammetry and amperometry techniques. The NiO/MoSe2/GCE was exhibited a linear response for the oxidation of glucose from 50 µM to 15.5 mM (R2 = 0.9842) at 0.5 V by amperometry. The sensor response time and the limit of detection were found to be 2 s and 0.6 µM for glucose. Moreover, selectivity of the NiO/MoSe2 sensor was tested in the presence of common interferent molecules such as hydrogen peroxide, fructose, lactose, ascorbic acid, uric acid, and dopamine. It was found that NiO/MoSe2/GCE did not respond to these interfering biomolecules. In addition, NiO/MoSe2/GCE had shown high stability, reproducibility and repeatability. Finally, the practical application of the sensor was demonstrated by detecting glucose in human blood serum with the acceptable recovery.Gayathri JeevanandhamKumaran VediappanZeid A. ALOthmanTariq AltalhiAshok K. SundramoorthyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gayathri Jeevanandham Kumaran Vediappan Zeid A. ALOthman Tariq Altalhi Ashok K. Sundramoorthy Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
description	Abstract Layered molybdenum diselenide (MoSe2) nanosheets were formed by the weak Van der Waals forces of attraction between Se and Mo atoms. MoSe2 has a larger space between the adjacent layers and smaller band gaps in the range of 0.85 to ~ 1.6 eV. In this study, MoSe2 nanosheets decorated nickel oxide (NiO) nanorods have been synthesized by hydrothermal method using sodium molybdate and selenium metal powder. NiO/MoSe2 composite formation was confirmed by powder X-ray diffraction analysis. In addition, the presence of MoSe2 nanosheets on NiO nanorods were confirmed by field emission scanning electron microscopy, high-resolution transmission electron microscopy and X-ray photoelectron spectroscopy. The Nyquist plots of NiO/MoSe2 coated glassy carbon electrode (GCE) was indicated that it had lower charge transfer resistance compared to NiO/GCE and MoSe2/GCE. Furthermore, as-prepared NiO/MoSe2/GCE was used to detect glucose in alkaline solution by cyclic voltammetry and amperometry techniques. The NiO/MoSe2/GCE was exhibited a linear response for the oxidation of glucose from 50 µM to 15.5 mM (R2 = 0.9842) at 0.5 V by amperometry. The sensor response time and the limit of detection were found to be 2 s and 0.6 µM for glucose. Moreover, selectivity of the NiO/MoSe2 sensor was tested in the presence of common interferent molecules such as hydrogen peroxide, fructose, lactose, ascorbic acid, uric acid, and dopamine. It was found that NiO/MoSe2/GCE did not respond to these interfering biomolecules. In addition, NiO/MoSe2/GCE had shown high stability, reproducibility and repeatability. Finally, the practical application of the sensor was demonstrated by detecting glucose in human blood serum with the acceptable recovery.
format	article
author	Gayathri Jeevanandham Kumaran Vediappan Zeid A. ALOthman Tariq Altalhi Ashok K. Sundramoorthy
author_facet	Gayathri Jeevanandham Kumaran Vediappan Zeid A. ALOthman Tariq Altalhi Ashok K. Sundramoorthy
author_sort	Gayathri Jeevanandham
title	Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
title_short	Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
title_full	Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
title_fullStr	Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
title_full_unstemmed	Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples
title_sort	fabrication of 2d-mose2 incorporated nio nanorods modified electrode for selective detection of glucose in serum samples
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7f6e0c9bba44e82be20f2cdba62f548
work_keys_str_mv	AT gayathrijeevanandham fabricationof2dmose2incorporatednionanorodsmodifiedelectrodeforselectivedetectionofglucoseinserumsamples AT kumaranvediappan fabricationof2dmose2incorporatednionanorodsmodifiedelectrodeforselectivedetectionofglucoseinserumsamples AT zeidaalothman fabricationof2dmose2incorporatednionanorodsmodifiedelectrodeforselectivedetectionofglucoseinserumsamples AT tariqaltalhi fabricationof2dmose2incorporatednionanorodsmodifiedelectrodeforselectivedetectionofglucoseinserumsamples AT ashokksundramoorthy fabricationof2dmose2incorporatednionanorodsmodifiedelectrodeforselectivedetectionofglucoseinserumsamples
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Fabrication of 2D-MoSe2 incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples

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