Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic propertie...

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Bibliographic Details
Main Authors: Lechuang Chen, Zhimin Feng, Hong Yue, Douglas Bazdar, Uri Mbonye, Chad Zender, Clifford V. Harding, Leslie Bruggeman, Jonathan Karn, Scott F. Sieg, Bingcheng Wang, Ge Jin
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/a7f985f13e9e43658dc1309ee8b12a66
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Summary:HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic properties of cancer cells through the activation of ERK1/2 signaling pathway.

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