Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic propertie...

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Main Authors:	Lechuang Chen, Zhimin Feng, Hong Yue, Douglas Bazdar, Uri Mbonye, Chad Zender, Clifford V. Harding, Leslie Bruggeman, Jonathan Karn, Scott F. Sieg, Bingcheng Wang, Ge Jin
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/a7f985f13e9e43658dc1309ee8b12a66
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spelling	oai:doaj.org-article:a7f985f13e9e43658dc1309ee8b12a662021-12-02T16:49:38ZExosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA10.1038/s41467-018-07006-22041-1723https://doaj.org/article/a7f985f13e9e43658dc1309ee8b12a662018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07006-2https://doaj.org/toc/2041-1723HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic properties of cancer cells through the activation of ERK1/2 signaling pathway.Lechuang ChenZhimin FengHong YueDouglas BazdarUri MbonyeChad ZenderClifford V. HardingLeslie BruggemanJonathan KarnScott F. SiegBingcheng WangGe JinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lechuang Chen Zhimin Feng Hong Yue Douglas Bazdar Uri Mbonye Chad Zender Clifford V. Harding Leslie Bruggeman Jonathan Karn Scott F. Sieg Bingcheng Wang Ge Jin Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
description	HIV patients have an increased risk of developing non-AIDS-defining cancers but the molecular mechanisms underlying this predisposition are unclear. Here the authors show that exosomes secreted by HIV-infected T cells or isolated from the blood of HIV-positive patients, stimulate oncogenic properties of cancer cells through the activation of ERK1/2 signaling pathway.
format	article
author	Lechuang Chen Zhimin Feng Hong Yue Douglas Bazdar Uri Mbonye Chad Zender Clifford V. Harding Leslie Bruggeman Jonathan Karn Scott F. Sieg Bingcheng Wang Ge Jin
author_facet	Lechuang Chen Zhimin Feng Hong Yue Douglas Bazdar Uri Mbonye Chad Zender Clifford V. Harding Leslie Bruggeman Jonathan Karn Scott F. Sieg Bingcheng Wang Ge Jin
author_sort	Lechuang Chen
title	Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
title_short	Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
title_full	Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
title_fullStr	Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
title_full_unstemmed	Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
title_sort	exosomes derived from hiv-1-infected cells promote growth and progression of cancer via hiv tar rna
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a7f985f13e9e43658dc1309ee8b12a66
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Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

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