Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China

Abstract While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. The resu...

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Autores principales:	Qiang Li, Yanhua Song, Hongmei Chen, Li Xie, Mengqiu Gao, Liping Ma, Yinxia Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7fd76fff1704b91aa6fe29f7a80ac42
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spelling	oai:doaj.org-article:a7fd76fff1704b91aa6fe29f7a80ac422021-12-02T15:08:47ZRetrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China10.1038/s41598-019-51695-82045-2322https://doaj.org/article/a7fd76fff1704b91aa6fe29f7a80ac422019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51695-8https://doaj.org/toc/2045-2322Abstract While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. The results were presented in terms of interquartile range (IQR) for age, and medians and percentages with respect to the categorical variables. One patient (3.6%) was immediately diagnosed; for 27 patients (96.4%), the median interval from the initial onset of symptoms to diagnosis was five weeks. Eight cases (28.6%) were microbiologically confirmed. 22 (78.6%) were pulmonary TB (PTB), while six (21.4%) were extrapulmonary TB (EPTB). In addition, eight (28.6%) were miliary TB and six (21.4%) were cerebral TB. 27 (96.4%) were cured and one (3.6%) died. 15 neonates were identified, nine of which were healthy. Two were small for the gestational age (SGA) and one was a stillbirth. Three had neonatal TB, one of which died. Nine were legal abortions and four were spontaneous abortions. Indeed, there was a substantial delay in the diagnosis of TB in the pregnant women and a high incidence of both miliary and cerebral TB was evident. With timely treatment, prognosis is positive.Qiang LiYanhua SongHongmei ChenLi XieMengqiu GaoLiping MaYinxia HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiang Li Yanhua Song Hongmei Chen Li Xie Mengqiu Gao Liping Ma Yinxia Huang Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
description	Abstract While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. The results were presented in terms of interquartile range (IQR) for age, and medians and percentages with respect to the categorical variables. One patient (3.6%) was immediately diagnosed; for 27 patients (96.4%), the median interval from the initial onset of symptoms to diagnosis was five weeks. Eight cases (28.6%) were microbiologically confirmed. 22 (78.6%) were pulmonary TB (PTB), while six (21.4%) were extrapulmonary TB (EPTB). In addition, eight (28.6%) were miliary TB and six (21.4%) were cerebral TB. 27 (96.4%) were cured and one (3.6%) died. 15 neonates were identified, nine of which were healthy. Two were small for the gestational age (SGA) and one was a stillbirth. Three had neonatal TB, one of which died. Nine were legal abortions and four were spontaneous abortions. Indeed, there was a substantial delay in the diagnosis of TB in the pregnant women and a high incidence of both miliary and cerebral TB was evident. With timely treatment, prognosis is positive.
format	article
author	Qiang Li Yanhua Song Hongmei Chen Li Xie Mengqiu Gao Liping Ma Yinxia Huang
author_facet	Qiang Li Yanhua Song Hongmei Chen Li Xie Mengqiu Gao Liping Ma Yinxia Huang
author_sort	Qiang Li
title	Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
title_short	Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
title_full	Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
title_fullStr	Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
title_full_unstemmed	Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China
title_sort	retrospective analysis of 28 cases of tuberculosis in pregnant women in china
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a7fd76fff1704b91aa6fe29f7a80ac42
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Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China

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