Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling

The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice and show that upregulation of funny current to the...

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Autores principales:	Pessah Yampolsky, Michael Koenen, Matias Mosqueira, Pascal Geschwill, Sebastian Nauck, Monika Witzenberger, Claudia Seyler, Thomas Fink, Mathieu Kruska, Claus Bruehl, Alexander P. Schwoerer, Heimo Ehmke, Rainer H. A. Fink, Andreas Draguhn, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
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spelling	oai:doaj.org-article:a8006cdc1e634c8e922f247e1bb32c742021-12-02T14:39:42ZAugmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling10.1038/s41467-019-11261-22041-1723https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c742019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11261-2https://doaj.org/toc/2041-1723The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice and show that upregulation of funny current to the levels observed in human heart failure alters calcium homeostasis leading to cardiac remodelling and arrhythmia.Pessah YampolskyMichael KoenenMatias MosqueiraPascal GeschwillSebastian NauckMonika WitzenbergerClaudia SeylerThomas FinkMathieu KruskaClaus BruehlAlexander P. SchwoererHeimo EhmkeRainer H. A. FinkAndreas DraguhnDierk ThomasHugo A. KatusPatrick A. SchweizerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pessah Yampolsky Michael Koenen Matias Mosqueira Pascal Geschwill Sebastian Nauck Monika Witzenberger Claudia Seyler Thomas Fink Mathieu Kruska Claus Bruehl Alexander P. Schwoerer Heimo Ehmke Rainer H. A. Fink Andreas Draguhn Dierk Thomas Hugo A. Katus Patrick A. Schweizer Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
description	The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice and show that upregulation of funny current to the levels observed in human heart failure alters calcium homeostasis leading to cardiac remodelling and arrhythmia.
format	article
author	Pessah Yampolsky Michael Koenen Matias Mosqueira Pascal Geschwill Sebastian Nauck Monika Witzenberger Claudia Seyler Thomas Fink Mathieu Kruska Claus Bruehl Alexander P. Schwoerer Heimo Ehmke Rainer H. A. Fink Andreas Draguhn Dierk Thomas Hugo A. Katus Patrick A. Schweizer
author_facet	Pessah Yampolsky Michael Koenen Matias Mosqueira Pascal Geschwill Sebastian Nauck Monika Witzenberger Claudia Seyler Thomas Fink Mathieu Kruska Claus Bruehl Alexander P. Schwoerer Heimo Ehmke Rainer H. A. Fink Andreas Draguhn Dierk Thomas Hugo A. Katus Patrick A. Schweizer
author_sort	Pessah Yampolsky
title	Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
title_short	Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
title_full	Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
title_fullStr	Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
title_full_unstemmed	Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
title_sort	augmentation of myocardial if dysregulates calcium homeostasis and causes adverse cardiac remodeling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
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Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling

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