Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes

Abstract Peripheral inflammation acts synergistically with hyperammonemia in inducing neurological alterations in cirrhotic patients with minimal hepatic encephalopathy (MHE). We hypothesized that appearance of MHE would be associated to some specific qualitative change in peripheral inflammation. T...

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Autores principales: Alba Mangas-Losada, Raquel García-García, Amparo Urios, Desamparados Escudero-García, Joan Tosca, Remedios Giner-Durán, Miguel Angel Serra, Carmina Montoliu, Vicente Felipo
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a8035e2fc38147e7a3ef9b015a69a6c8
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spelling oai:doaj.org-article:a8035e2fc38147e7a3ef9b015a69a6c82021-12-02T16:08:20ZMinimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes10.1038/s41598-017-05938-12045-2322https://doaj.org/article/a8035e2fc38147e7a3ef9b015a69a6c82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05938-1https://doaj.org/toc/2045-2322Abstract Peripheral inflammation acts synergistically with hyperammonemia in inducing neurological alterations in cirrhotic patients with minimal hepatic encephalopathy (MHE). We hypothesized that appearance of MHE would be associated to some specific qualitative change in peripheral inflammation. The aim of this work was to characterize the changes in peripheral inflammation associated to appearance of MHE. We analyzed it by immunophenotyping and cytokine profile analysis, in cirrhotic patients without or with MHE and controls. The main alterations associated specifically with MHE are: 1) increased activation of all subtypes of CD4+ T-lymphocytes, with the increased expression of CD69; 2) increased amount of CD4+CD28− T lymphocytes, associated with increased levels of CX3CL1 and of IL-15; 3) increased differentiation of CD4+ T lymphocytes to Th follicular and Th22; 4) increased activation of B lymphocytes and serum IgG. This study has identified some specific alterations of the immune system associated with appearance of the neurological alterations in MHE patients.Alba Mangas-LosadaRaquel García-GarcíaAmparo UriosDesamparados Escudero-GarcíaJoan ToscaRemedios Giner-DuránMiguel Angel SerraCarmina MontoliuVicente FelipoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alba Mangas-Losada
Raquel García-García
Amparo Urios
Desamparados Escudero-García
Joan Tosca
Remedios Giner-Durán
Miguel Angel Serra
Carmina Montoliu
Vicente Felipo
Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
description Abstract Peripheral inflammation acts synergistically with hyperammonemia in inducing neurological alterations in cirrhotic patients with minimal hepatic encephalopathy (MHE). We hypothesized that appearance of MHE would be associated to some specific qualitative change in peripheral inflammation. The aim of this work was to characterize the changes in peripheral inflammation associated to appearance of MHE. We analyzed it by immunophenotyping and cytokine profile analysis, in cirrhotic patients without or with MHE and controls. The main alterations associated specifically with MHE are: 1) increased activation of all subtypes of CD4+ T-lymphocytes, with the increased expression of CD69; 2) increased amount of CD4+CD28− T lymphocytes, associated with increased levels of CX3CL1 and of IL-15; 3) increased differentiation of CD4+ T lymphocytes to Th follicular and Th22; 4) increased activation of B lymphocytes and serum IgG. This study has identified some specific alterations of the immune system associated with appearance of the neurological alterations in MHE patients.
format article
author Alba Mangas-Losada
Raquel García-García
Amparo Urios
Desamparados Escudero-García
Joan Tosca
Remedios Giner-Durán
Miguel Angel Serra
Carmina Montoliu
Vicente Felipo
author_facet Alba Mangas-Losada
Raquel García-García
Amparo Urios
Desamparados Escudero-García
Joan Tosca
Remedios Giner-Durán
Miguel Angel Serra
Carmina Montoliu
Vicente Felipo
author_sort Alba Mangas-Losada
title Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
title_short Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
title_full Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
title_fullStr Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
title_full_unstemmed Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes
title_sort minimal hepatic encephalopathy is associated with expansion and activation of cd4+cd28−, th22 and tfh and b lymphocytes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a8035e2fc38147e7a3ef9b015a69a6c8
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