Transplanting a Microbial Organ: the Good, the Bad, and the Unknown

ABSTRACT Fecal microbiota transplantation (FMT) has received increased attention as a therapy for correcting intestinal dysbiosis and restoring a state of health in patients suffering from either recalcitrant infection by Clostridium difficile or more complex disease states, such as inflammatory bow...

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Autores principales:	Dionysios A. Antonopoulos, Eugene B. Chang
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a8046793e6dc4b86b2cfd8a7001f709b
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spelling	oai:doaj.org-article:a8046793e6dc4b86b2cfd8a7001f709b2021-11-15T15:50:17ZTransplanting a Microbial Organ: the Good, the Bad, and the Unknown10.1128/mBio.00572-162150-7511https://doaj.org/article/a8046793e6dc4b86b2cfd8a7001f709b2016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00572-16https://doaj.org/toc/2150-7511ABSTRACT Fecal microbiota transplantation (FMT) has received increased attention as a therapy for correcting intestinal dysbiosis and restoring a state of health in patients suffering from either recalcitrant infection by Clostridium difficile or more complex disease states, such as inflammatory bowel disease (IBD). The “gut microbial organ” from the donor that is used in these transplants may serve to transfer genetic material between donor and recipient via virus-like particles, specifically bacteriophages, that infect the bacterial component of the microbiota. The recently published study by Chehoud et al. provides evidence for not only the transfer of bacteriophages during FMT but also the transfer of multiple populations of bacteriophages to recipients from the donor microbiota used (C. Chehoud et al., mBio 7:e00322-16, 2016, http://dx.doi.org/10.1128/mBio.00322-16). While the clinical significance of these findings remains unclear, nothing short of a diligent and persistent effort is needed to define the intended and unintended consequences of FMT.Dionysios A. AntonopoulosEugene B. ChangAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Dionysios A. Antonopoulos Eugene B. Chang Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
description	ABSTRACT Fecal microbiota transplantation (FMT) has received increased attention as a therapy for correcting intestinal dysbiosis and restoring a state of health in patients suffering from either recalcitrant infection by Clostridium difficile or more complex disease states, such as inflammatory bowel disease (IBD). The “gut microbial organ” from the donor that is used in these transplants may serve to transfer genetic material between donor and recipient via virus-like particles, specifically bacteriophages, that infect the bacterial component of the microbiota. The recently published study by Chehoud et al. provides evidence for not only the transfer of bacteriophages during FMT but also the transfer of multiple populations of bacteriophages to recipients from the donor microbiota used (C. Chehoud et al., mBio 7:e00322-16, 2016, http://dx.doi.org/10.1128/mBio.00322-16). While the clinical significance of these findings remains unclear, nothing short of a diligent and persistent effort is needed to define the intended and unintended consequences of FMT.
format	article
author	Dionysios A. Antonopoulos Eugene B. Chang
author_facet	Dionysios A. Antonopoulos Eugene B. Chang
author_sort	Dionysios A. Antonopoulos
title	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
title_short	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
title_full	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
title_fullStr	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
title_full_unstemmed	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown
title_sort	transplanting a microbial organ: the good, the bad, and the unknown
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/a8046793e6dc4b86b2cfd8a7001f709b
work_keys_str_mv	AT dionysiosaantonopoulos transplantingamicrobialorganthegoodthebadandtheunknown AT eugenebchang transplantingamicrobialorganthegoodthebadandtheunknown
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Transplanting a Microbial Organ: the Good, the Bad, and the Unknown

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