ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.

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Detalles Bibliográficos
Autores principales:	Geneviève Deblois, Harvey W. Smith, Ingrid S. Tam, Simon-Pierre Gravel, Maxime Caron, Paul Savage, David P. Labbé, Louis R. Bégin, Michel L. Tremblay, Morag Park, Guillaume Bourque, Julie St-Pierre, William J. Muller, Vincent Giguère
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a807b71593d5451987bf6593688f61a3
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spelling	oai:doaj.org-article:a807b71593d5451987bf6593688f61a32021-12-02T17:32:36ZERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer10.1038/ncomms121562041-1723https://doaj.org/article/a807b71593d5451987bf6593688f61a32016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12156https://doaj.org/toc/2041-1723Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.Geneviève DebloisHarvey W. SmithIngrid S. TamSimon-Pierre GravelMaxime CaronPaul SavageDavid P. LabbéLouis R. BéginMichel L. TremblayMorag ParkGuillaume BourqueJulie St-PierreWilliam J. MullerVincent GiguèreNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
description	Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.
format	article
author	Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère
author_facet	Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère
author_sort	Geneviève Deblois
title	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_short	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_full	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_fullStr	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_full_unstemmed	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_sort	errα mediates metabolic adaptations driving lapatinib resistance in breast cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a807b71593d5451987bf6593688f61a3
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ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

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