Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection

Abstract Segregation distortion is a common phenomenon found in most genetic mapping studies and is an important resource to dissect the mechanism of action in gene loci that cause deviation. Marine animals possess high genetic diversity and genomic heterozygosity, they therefore are ideal model org...

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Autores principales:	Qiang Fu, Xianhong Meng, Sheng Luan, Baolong Chen, Jiawang Cao, Xupeng Li, Jie Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8083a2dee114921aa0ed42dd4a7096b
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spelling	oai:doaj.org-article:a8083a2dee114921aa0ed42dd4a7096b2021-12-02T11:43:44ZSegregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection10.1038/s41598-020-78389-w2045-2322https://doaj.org/article/a8083a2dee114921aa0ed42dd4a7096b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78389-whttps://doaj.org/toc/2045-2322Abstract Segregation distortion is a common phenomenon found in most genetic mapping studies and is an important resource to dissect the mechanism of action in gene loci that cause deviation. Marine animals possess high genetic diversity and genomic heterozygosity, they therefore are ideal model organisms to study segregation distortion induced by selection. In the present study, we constructed a full-sib family of Fenneropenaeus chinensis and exerted high-intensity selection on 10,000 incipient progenies. 2b-RAD method was employed in remaining 273 individuals to develop genome-wide SNPs for segregating analysis and 41,612 SNPs were developed. 50.77% of 32,229 high-quality representative markers deviated from the expected Mendelian ratio. Results showed that most of these distorted markers (91.57%) were influenced at zygotic level. Heterozygote excess (53.07%) and homozygous deletions (41.96%) may both play an important role, sum of which explained 95.03% of distortion after fertilization. However, further results identified highly probable linkage among deleterious alleles, which may account for a considerable portion of heterozygote excess rather than single locus with heterozygote advantage. Results of this study support a major role of deleterious alleles in genetic load, thus in favor of partial dominance hypothesis. It would also offer necessary recommendations for the formulation of breeding strategy in shrimps.Qiang FuXianhong MengSheng LuanBaolong ChenJiawang CaoXupeng LiJie KongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiang Fu Xianhong Meng Sheng Luan Baolong Chen Jiawang Cao Xupeng Li Jie Kong Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
description	Abstract Segregation distortion is a common phenomenon found in most genetic mapping studies and is an important resource to dissect the mechanism of action in gene loci that cause deviation. Marine animals possess high genetic diversity and genomic heterozygosity, they therefore are ideal model organisms to study segregation distortion induced by selection. In the present study, we constructed a full-sib family of Fenneropenaeus chinensis and exerted high-intensity selection on 10,000 incipient progenies. 2b-RAD method was employed in remaining 273 individuals to develop genome-wide SNPs for segregating analysis and 41,612 SNPs were developed. 50.77% of 32,229 high-quality representative markers deviated from the expected Mendelian ratio. Results showed that most of these distorted markers (91.57%) were influenced at zygotic level. Heterozygote excess (53.07%) and homozygous deletions (41.96%) may both play an important role, sum of which explained 95.03% of distortion after fertilization. However, further results identified highly probable linkage among deleterious alleles, which may account for a considerable portion of heterozygote excess rather than single locus with heterozygote advantage. Results of this study support a major role of deleterious alleles in genetic load, thus in favor of partial dominance hypothesis. It would also offer necessary recommendations for the formulation of breeding strategy in shrimps.
format	article
author	Qiang Fu Xianhong Meng Sheng Luan Baolong Chen Jiawang Cao Xupeng Li Jie Kong
author_facet	Qiang Fu Xianhong Meng Sheng Luan Baolong Chen Jiawang Cao Xupeng Li Jie Kong
author_sort	Qiang Fu
title	Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
title_short	Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
title_full	Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
title_fullStr	Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
title_full_unstemmed	Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection
title_sort	segregation distortion: high genetic load suggested by a chinese shrimp family under high-intensity selection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a8083a2dee114921aa0ed42dd4a7096b
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_version_	1718395361324695552

Segregation distortion: high genetic load suggested by a Chinese shrimp family under high-intensity selection

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