Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review

Purpose: Hypertonic fluids such as mannitol and half-molar sodium lactate are given to treat intracranial hypertension in patients with severe traumatic brain injury (TBI). In this study, sodium lactate was compared to mannitol in patients with TBI to investigate the efficacy in reducing intracrania...

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Autores principales:	Abdul Hafid Bajamal, Tedy Apriawan, I.G.M. Aswin R. Ranuh, Franco Servadei, Muhammad Faris, Asra Al Fauzi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Half-molar sodium lactate Mannitol Traumatic brain injuries Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a8092a7c828841149837c67366a3ed70
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spelling	oai:doaj.org-article:a8092a7c828841149837c67366a3ed702021-11-18T04:43:45ZComparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review1008-127510.1016/j.cjtee.2021.07.005https://doaj.org/article/a8092a7c828841149837c67366a3ed702021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1008127521001176https://doaj.org/toc/1008-1275Purpose: Hypertonic fluids such as mannitol and half-molar sodium lactate are given to treat intracranial hypertension in patients with severe traumatic brain injury (TBI). In this study, sodium lactate was compared to mannitol in patients with TBI to investigate the efficacy in reducing intracranial pressure (ICP). Methods: This study was a systematic review with literature research on articles published in any year in the databases of PubMed, ScienceDirect, Asian Journal of Neurosurgery, and Cochrane Central Register of Controlled Trials. The keywords were “half-molar sodium lactate”, “mannitol”, “cerebral edema or brain swelling”, and “severe traumatic brain injury”. The inclusion criteria were (1) studies published in English, (2) randomized control trials or retrospective/prospective studies on TBI patients, and (3) therapies including half-molar sodium lactate and mannitol and (4) sufficient data such as mean difference (MD) and risk ratio (RR). Data analysis was conducted using Review Manager 5.3. Results: From 1499 studies, a total of 8 studies were eligible. Mannitol group reduced ICP of 0.65 times (MD 0.65; p = 0.64) and improved cerebral perfusion pressure of 0.61 times (MD 0.61; p = 0.88), better than the half-molar group of sodium lactate. But the half-molar group of sodium lactate maintained the mean arterial pressure level of 0.86 times, better than the mannitol group (MD 0.86; p = 0.09). Conclusion: Half-molar sodium lactate is as effective as mannitol in reducing ICP in the early phase of brain injury, superior over mannitol in an extended period. It is able to prevent intracranial hypertension and give better brain tissue perfusion as well as more stable hemodynamics. Blood osmolarity is a concern as it increases serum sodium.Abdul Hafid BajamalTedy ApriawanI.G.M. Aswin R. RanuhFranco ServadeiMuhammad FarisAsra Al FauziElsevierarticleHalf-molar sodium lactateMannitolTraumatic brain injuriesMedicine (General)R5-920ENChinese Journal of Traumatology, Vol 24, Iss 6, Pp 344-349 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Half-molar sodium lactate Mannitol Traumatic brain injuries Medicine (General) R5-920
spellingShingle	Half-molar sodium lactate Mannitol Traumatic brain injuries Medicine (General) R5-920 Abdul Hafid Bajamal Tedy Apriawan I.G.M. Aswin R. Ranuh Franco Servadei Muhammad Faris Asra Al Fauzi Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
description	Purpose: Hypertonic fluids such as mannitol and half-molar sodium lactate are given to treat intracranial hypertension in patients with severe traumatic brain injury (TBI). In this study, sodium lactate was compared to mannitol in patients with TBI to investigate the efficacy in reducing intracranial pressure (ICP). Methods: This study was a systematic review with literature research on articles published in any year in the databases of PubMed, ScienceDirect, Asian Journal of Neurosurgery, and Cochrane Central Register of Controlled Trials. The keywords were “half-molar sodium lactate”, “mannitol”, “cerebral edema or brain swelling”, and “severe traumatic brain injury”. The inclusion criteria were (1) studies published in English, (2) randomized control trials or retrospective/prospective studies on TBI patients, and (3) therapies including half-molar sodium lactate and mannitol and (4) sufficient data such as mean difference (MD) and risk ratio (RR). Data analysis was conducted using Review Manager 5.3. Results: From 1499 studies, a total of 8 studies were eligible. Mannitol group reduced ICP of 0.65 times (MD 0.65; p = 0.64) and improved cerebral perfusion pressure of 0.61 times (MD 0.61; p = 0.88), better than the half-molar group of sodium lactate. But the half-molar group of sodium lactate maintained the mean arterial pressure level of 0.86 times, better than the mannitol group (MD 0.86; p = 0.09). Conclusion: Half-molar sodium lactate is as effective as mannitol in reducing ICP in the early phase of brain injury, superior over mannitol in an extended period. It is able to prevent intracranial hypertension and give better brain tissue perfusion as well as more stable hemodynamics. Blood osmolarity is a concern as it increases serum sodium.
format	article
author	Abdul Hafid Bajamal Tedy Apriawan I.G.M. Aswin R. Ranuh Franco Servadei Muhammad Faris Asra Al Fauzi
author_facet	Abdul Hafid Bajamal Tedy Apriawan I.G.M. Aswin R. Ranuh Franco Servadei Muhammad Faris Asra Al Fauzi
author_sort	Abdul Hafid Bajamal
title	Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
title_short	Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
title_full	Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
title_fullStr	Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
title_full_unstemmed	Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review
title_sort	comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: a systematic review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a8092a7c828841149837c67366a3ed70
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Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury: A systematic review

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