Cerebrovascular accidents in patients with type 2 diabetes mellitus

Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemi...

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Autores principales:	Sergey Valentinovich Kakorin, E V Tulyakova, K V Voronkova, Ashot Musaelovich Mkrtumyan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	cerebrovascular accident cardiovascular disease type 2 diabetes mellitus macroangiopathy monckeberg's arteriosclerosis heart failure indirect anticoagulants neuroprotectors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/a80fd28e9a6e45ac8d20946f5175c66c
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spelling	oai:doaj.org-article:a80fd28e9a6e45ac8d20946f5175c66c2021-11-14T09:00:17ZCerebrovascular accidents in patients with type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-3599https://doaj.org/article/a80fd28e9a6e45ac8d20946f5175c66c2013-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3599https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemia promotes CA risks by induction of protein glycosylation, elevation of blood plasma atherogenic potential, activation of coagulation system with higher risk for thrombosis and disturbance of microcirculation on tissue and organ lev- els. Influence of hyperglycemia on severity and extent of neurologic damage is still under evaluation. Development of macroangiopathy is thought to be associated with media calcification, distal polyneuropathy and renal disorders, all of which are cardiovascular risk factors. Application of so-called metabolic drugs resulted in certain disillusionment, as these agents failed to prove their efficacy during clinical trials. Incidence of pulmonary edema in patients with ischemic CA and T2DM is important as it dictates the necessity for use of loop diuretics. Incidence and severity of heart failure and its correlation with degree of glycemic disorders, incidence of pulmonary em- bolism, as well as tactics of management and prognosis in patients with ischemic CA and T2DM, remains a relevant research problem.Sergey Valentinovich KakorinE V TulyakovaK V VoronkovaAshot Musaelovich MkrtumyanEndocrinology Research Centrearticlecerebrovascular accidentcardiovascular diseasetype 2 diabetes mellitusmacroangiopathymonckeberg's arteriosclerosisheart failureindirect anticoagulantsneuroprotectorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 1, Pp 63-70 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	cerebrovascular accident cardiovascular disease type 2 diabetes mellitus macroangiopathy monckeberg's arteriosclerosis heart failure indirect anticoagulants neuroprotectors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	cerebrovascular accident cardiovascular disease type 2 diabetes mellitus macroangiopathy monckeberg's arteriosclerosis heart failure indirect anticoagulants neuroprotectors Nutritional diseases. Deficiency diseases RC620-627 Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan Cerebrovascular accidents in patients with type 2 diabetes mellitus
description	Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemia promotes CA risks by induction of protein glycosylation, elevation of blood plasma atherogenic potential, activation of coagulation system with higher risk for thrombosis and disturbance of microcirculation on tissue and organ lev- els. Influence of hyperglycemia on severity and extent of neurologic damage is still under evaluation. Development of macroangiopathy is thought to be associated with media calcification, distal polyneuropathy and renal disorders, all of which are cardiovascular risk factors. Application of so-called metabolic drugs resulted in certain disillusionment, as these agents failed to prove their efficacy during clinical trials. Incidence of pulmonary edema in patients with ischemic CA and T2DM is important as it dictates the necessity for use of loop diuretics. Incidence and severity of heart failure and its correlation with degree of glycemic disorders, incidence of pulmonary em- bolism, as well as tactics of management and prognosis in patients with ischemic CA and T2DM, remains a relevant research problem.
format	article
author	Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan
author_facet	Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan
author_sort	Sergey Valentinovich Kakorin
title	Cerebrovascular accidents in patients with type 2 diabetes mellitus
title_short	Cerebrovascular accidents in patients with type 2 diabetes mellitus
title_full	Cerebrovascular accidents in patients with type 2 diabetes mellitus
title_fullStr	Cerebrovascular accidents in patients with type 2 diabetes mellitus
title_full_unstemmed	Cerebrovascular accidents in patients with type 2 diabetes mellitus
title_sort	cerebrovascular accidents in patients with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/a80fd28e9a6e45ac8d20946f5175c66c
work_keys_str_mv	AT sergeyvalentinovichkakorin cerebrovascularaccidentsinpatientswithtype2diabetesmellitus AT evtulyakova cerebrovascularaccidentsinpatientswithtype2diabetesmellitus AT kvvoronkova cerebrovascularaccidentsinpatientswithtype2diabetesmellitus AT ashotmusaelovichmkrtumyan cerebrovascularaccidentsinpatientswithtype2diabetesmellitus
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Cerebrovascular accidents in patients with type 2 diabetes mellitus

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