High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.

To better design association studies for complex traits in isolated populations it's important to understand how history and isolation moulded the genetic features of different communities. Population isolates should not "a priori" be considered homogeneous, even if the communities ar...

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Autores principales:	Giorgio Pistis, Ignazio Piras, Nicola Pirastu, Ivana Persico, Alessandro Sassu, Andrea Picciau, Dionigio Prodi, Cristina Fraumene, Evelina Mocci, Maria Teresa Manias, Rossano Atzeni, Massimiliano Cosso, Mario Pirastu, Andrea Angius
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a810b162271342638fb0494fcd2f77ee
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spelling	oai:doaj.org-article:a810b162271342638fb0494fcd2f77ee2021-11-25T06:17:00ZHigh differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.1932-620310.1371/journal.pone.0004654https://doaj.org/article/a810b162271342638fb0494fcd2f77ee2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19247500/?tool=EBIhttps://doaj.org/toc/1932-6203To better design association studies for complex traits in isolated populations it's important to understand how history and isolation moulded the genetic features of different communities. Population isolates should not "a priori" be considered homogeneous, even if the communities are not distant and part of a small region. We studied a particular area of Sardinia called Ogliastra, characterized by the presence of several distinct villages that display different history, immigration events and population size. Cultural and geographic isolation characterized the history of these communities. We determined LD parameters in 8 villages and defined population structure through high density SNPs (about 360 K) on 360 unrelated people (45 selected samples from each village). These isolates showed differences in LD values and LD map length. Five of these villages show high LD values probably due to their reduced population size and extreme isolation. High genetic differentiation among villages was detected. Moreover population structure analysis revealed a high correlation between genetic and geographic distances. Our study indicates that history, geography and biodemography have influenced the genetic features of Ogliastra communities producing differences in LD and population structure. All these data demonstrate that we can consider each village an isolate with specific characteristics. We suggest that, in order to optimize the study design of complex traits, a thorough characterization of genetic features is useful to identify the presence of sub-populations and stratification within genetic isolates.Giorgio PistisIgnazio PirasNicola PirastuIvana PersicoAlessandro SassuAndrea PicciauDionigio ProdiCristina FraumeneEvelina MocciMaria Teresa ManiasRossano AtzeniMassimiliano CossoMario PirastuAndrea AngiusAndrea AngiusPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4654 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giorgio Pistis Ignazio Piras Nicola Pirastu Ivana Persico Alessandro Sassu Andrea Picciau Dionigio Prodi Cristina Fraumene Evelina Mocci Maria Teresa Manias Rossano Atzeni Massimiliano Cosso Mario Pirastu Andrea Angius Andrea Angius High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
description	To better design association studies for complex traits in isolated populations it's important to understand how history and isolation moulded the genetic features of different communities. Population isolates should not "a priori" be considered homogeneous, even if the communities are not distant and part of a small region. We studied a particular area of Sardinia called Ogliastra, characterized by the presence of several distinct villages that display different history, immigration events and population size. Cultural and geographic isolation characterized the history of these communities. We determined LD parameters in 8 villages and defined population structure through high density SNPs (about 360 K) on 360 unrelated people (45 selected samples from each village). These isolates showed differences in LD values and LD map length. Five of these villages show high LD values probably due to their reduced population size and extreme isolation. High genetic differentiation among villages was detected. Moreover population structure analysis revealed a high correlation between genetic and geographic distances. Our study indicates that history, geography and biodemography have influenced the genetic features of Ogliastra communities producing differences in LD and population structure. All these data demonstrate that we can consider each village an isolate with specific characteristics. We suggest that, in order to optimize the study design of complex traits, a thorough characterization of genetic features is useful to identify the presence of sub-populations and stratification within genetic isolates.
format	article
author	Giorgio Pistis Ignazio Piras Nicola Pirastu Ivana Persico Alessandro Sassu Andrea Picciau Dionigio Prodi Cristina Fraumene Evelina Mocci Maria Teresa Manias Rossano Atzeni Massimiliano Cosso Mario Pirastu Andrea Angius Andrea Angius
author_facet	Giorgio Pistis Ignazio Piras Nicola Pirastu Ivana Persico Alessandro Sassu Andrea Picciau Dionigio Prodi Cristina Fraumene Evelina Mocci Maria Teresa Manias Rossano Atzeni Massimiliano Cosso Mario Pirastu Andrea Angius Andrea Angius
author_sort	Giorgio Pistis
title	High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
title_short	High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
title_full	High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
title_fullStr	High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
title_full_unstemmed	High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
title_sort	high differentiation among eight villages in a secluded area of sardinia revealed by genome-wide high density snps analysis.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/a810b162271342638fb0494fcd2f77ee
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High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.

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