Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis

Introduction Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory e...

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Autores principales:	Serdar Turkyilmaz, Arif Burak Cekic, Arif Usta, Etem Alhan, Birgül Vanizor Kural, Cengiz Ercin, Kutay Sağlam
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	pancreatitis rat ethyl pyruvate acute necrotizing pancreatitis Medicine R
Acceso en línea:	https://doaj.org/article/a81247c92ddf402db3426f6bf22798da
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spelling	oai:doaj.org-article:a81247c92ddf402db3426f6bf22798da2021-12-02T18:39:09ZEthyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis1734-19221896-915110.5114/aoms.2017.65231https://doaj.org/article/a81247c92ddf402db3426f6bf22798da2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Ethyl-pyruvate-treatment-ameliorates-pancreatic-damage-evidence-from-a-rat-model,65172,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress. Material and methods Fifty-two adult male Sprague-Dawley rats were divided into four groups: sham + saline, sham + EP, ANP + saline, and ANP + EP. The ANP was induced by glycodeoxycholic acid and cerulein. Animals were sacrificed at 48 h and biochemical, hematological, and histological markers of ANP and inflammation were assessed. The extent of mortality, systemic cardiorespiratory variables, pancreatic microcirculation, renal/hepatic functions, acinar cell injury and enzyme markers for pancreas and lung tissues were investigated. Results The EP-treated ANP group presented significantly lower mortality than the untreated ANP group (44% (7/16) vs. 19% (3/16), respectively, p < 0.05). Administration of EP resulted in significantly lower levels of IL-6 (ANP + saline: 5470 ±280 vs. ANP + EP: 2250 ±180 pg/ml, p < 0.05). Compared with the ANP group, the ANP + EP group had a lower pancreatic necrosis score (1.45 ±0.2 vs. 0.96 ±0.2, p < 0.05). Moreover, intraperitoneal EP administration had a positive effect on most indices of pancreatitis (amylase and alanine transaminase levels) and lung damage (except lung malondialdehyde levels) as they decreased towards baseline values. Conclusions The results from this experimental study indicate that EP, a nontoxic chemical approved by the Food and Drug Administration as a food additive, provides positive effects on the course of pancreatitis, suggesting potential usefulness in management of ANP.Serdar TurkyilmazArif Burak CekicArif UstaEtem AlhanBirgül Vanizor KuralCengiz ErcinKutay SağlamTermedia Publishing Housearticlepancreatitisratethyl pyruvateacute necrotizing pancreatitispancreatitisethyl pyruvateMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 232-239 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatitis rat ethyl pyruvate acute necrotizing pancreatitis pancreatitis ethyl pyruvate Medicine R
spellingShingle	pancreatitis rat ethyl pyruvate acute necrotizing pancreatitis pancreatitis ethyl pyruvate Medicine R Serdar Turkyilmaz Arif Burak Cekic Arif Usta Etem Alhan Birgül Vanizor Kural Cengiz Ercin Kutay Sağlam Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
description	Introduction Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress. Material and methods Fifty-two adult male Sprague-Dawley rats were divided into four groups: sham + saline, sham + EP, ANP + saline, and ANP + EP. The ANP was induced by glycodeoxycholic acid and cerulein. Animals were sacrificed at 48 h and biochemical, hematological, and histological markers of ANP and inflammation were assessed. The extent of mortality, systemic cardiorespiratory variables, pancreatic microcirculation, renal/hepatic functions, acinar cell injury and enzyme markers for pancreas and lung tissues were investigated. Results The EP-treated ANP group presented significantly lower mortality than the untreated ANP group (44% (7/16) vs. 19% (3/16), respectively, p < 0.05). Administration of EP resulted in significantly lower levels of IL-6 (ANP + saline: 5470 ±280 vs. ANP + EP: 2250 ±180 pg/ml, p < 0.05). Compared with the ANP group, the ANP + EP group had a lower pancreatic necrosis score (1.45 ±0.2 vs. 0.96 ±0.2, p < 0.05). Moreover, intraperitoneal EP administration had a positive effect on most indices of pancreatitis (amylase and alanine transaminase levels) and lung damage (except lung malondialdehyde levels) as they decreased towards baseline values. Conclusions The results from this experimental study indicate that EP, a nontoxic chemical approved by the Food and Drug Administration as a food additive, provides positive effects on the course of pancreatitis, suggesting potential usefulness in management of ANP.
format	article
author	Serdar Turkyilmaz Arif Burak Cekic Arif Usta Etem Alhan Birgül Vanizor Kural Cengiz Ercin Kutay Sağlam
author_facet	Serdar Turkyilmaz Arif Burak Cekic Arif Usta Etem Alhan Birgül Vanizor Kural Cengiz Ercin Kutay Sağlam
author_sort	Serdar Turkyilmaz
title	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
title_short	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
title_full	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
title_fullStr	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
title_full_unstemmed	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
title_sort	ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/a81247c92ddf402db3426f6bf22798da
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Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis

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