Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance

Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy...

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Autores principales:	Hannah Piepenbreier, Angelika Diehl, Georg Fritz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a814415456d14601a61c11483ea4c660
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spelling	oai:doaj.org-article:a814415456d14601a61c11483ea4c6602021-12-02T17:02:08ZMinimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance10.1038/s41467-019-10673-42041-1723https://doaj.org/article/a814415456d14601a61c11483ea4c6602019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10673-4https://doaj.org/toc/2041-1723Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.Hannah PiepenbreierAngelika DiehlGeorg FritzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah Piepenbreier Angelika Diehl Georg Fritz Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
description	Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.
format	article
author	Hannah Piepenbreier Angelika Diehl Georg Fritz
author_facet	Hannah Piepenbreier Angelika Diehl Georg Fritz
author_sort	Hannah Piepenbreier
title	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_short	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_full	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_fullStr	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_full_unstemmed	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_sort	minimal exposure of lipid ii cycle intermediates triggers cell wall antibiotic resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a814415456d14601a61c11483ea4c660
work_keys_str_mv	AT hannahpiepenbreier minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance AT angelikadiehl minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance AT georgfritz minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance
_version_	1718381988562337792

Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance

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