Airway cilia recovery post lung transplantation

Abstract Background Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation...

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Autores principales:	Randy Suryadinata, Kovi Levin, Lynda Holsworth, Miranda Paraskeva, Philip Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cilia lung transplantation mucociliary clearance Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a8146d7516a9417893365c9c22a5da93
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spelling	oai:doaj.org-article:a8146d7516a9417893365c9c22a5da932021-11-12T19:57:15ZAirway cilia recovery post lung transplantation2050-452710.1002/iid3.527https://doaj.org/article/a8146d7516a9417893365c9c22a5da932021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.527https://doaj.org/toc/2050-4527Abstract Background Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airway infection, which we hypothesize may be caused by impaired cilia function. Methods Airway cilia beating pattern (CBP) and frequency (CBF) were studied on brushing samples taken from above and below the transplant anastomosis of adult lung transplant recipients (n = 20) during routine bronchoscopies at 6, 12, and 26 weeks posttransplant. Bronchoaveolar Lavage (BAL) samples were also collected at each time points. Results At 6 weeks posttransplant (n = 16), CBP from the donated lung showed reduced beating amplitude with the overall CBF 2.28 Hz slower than the patients' native upper airway cilia (median ± SIQR: 5.36 ± 0.93 Hz vs. 7.64 ± 0.92 Hz, p value < .001). At 12 weeks (n = 16), donor lungs CBP showed recovery with the difference in CBF reduced to 0.74 Hz (6.36 ± 1.46 Hz vs. 7.10 ± 0.86 Hz, p value < .05). Impaired cilia function was not associated with positive BAL cultures. Conclusion Reduced cilia function is evident in the first 12 weeks post lung transplant, with both CBP and CBF returning to levels of function indistinguishable to the patients' upper airway cilia beyond this time.Randy SuryadinataKovi LevinLynda HolsworthMiranda ParaskevaPhilip RobinsonWileyarticlecilialung transplantationmucociliary clearanceImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1716-1723 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cilia lung transplantation mucociliary clearance Immunologic diseases. Allergy RC581-607
spellingShingle	cilia lung transplantation mucociliary clearance Immunologic diseases. Allergy RC581-607 Randy Suryadinata Kovi Levin Lynda Holsworth Miranda Paraskeva Philip Robinson Airway cilia recovery post lung transplantation
description	Abstract Background Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airway infection, which we hypothesize may be caused by impaired cilia function. Methods Airway cilia beating pattern (CBP) and frequency (CBF) were studied on brushing samples taken from above and below the transplant anastomosis of adult lung transplant recipients (n = 20) during routine bronchoscopies at 6, 12, and 26 weeks posttransplant. Bronchoaveolar Lavage (BAL) samples were also collected at each time points. Results At 6 weeks posttransplant (n = 16), CBP from the donated lung showed reduced beating amplitude with the overall CBF 2.28 Hz slower than the patients' native upper airway cilia (median ± SIQR: 5.36 ± 0.93 Hz vs. 7.64 ± 0.92 Hz, p value < .001). At 12 weeks (n = 16), donor lungs CBP showed recovery with the difference in CBF reduced to 0.74 Hz (6.36 ± 1.46 Hz vs. 7.10 ± 0.86 Hz, p value < .05). Impaired cilia function was not associated with positive BAL cultures. Conclusion Reduced cilia function is evident in the first 12 weeks post lung transplant, with both CBP and CBF returning to levels of function indistinguishable to the patients' upper airway cilia beyond this time.
format	article
author	Randy Suryadinata Kovi Levin Lynda Holsworth Miranda Paraskeva Philip Robinson
author_facet	Randy Suryadinata Kovi Levin Lynda Holsworth Miranda Paraskeva Philip Robinson
author_sort	Randy Suryadinata
title	Airway cilia recovery post lung transplantation
title_short	Airway cilia recovery post lung transplantation
title_full	Airway cilia recovery post lung transplantation
title_fullStr	Airway cilia recovery post lung transplantation
title_full_unstemmed	Airway cilia recovery post lung transplantation
title_sort	airway cilia recovery post lung transplantation
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a8146d7516a9417893365c9c22a5da93
work_keys_str_mv	AT randysuryadinata airwayciliarecoverypostlungtransplantation AT kovilevin airwayciliarecoverypostlungtransplantation AT lyndaholsworth airwayciliarecoverypostlungtransplantation AT mirandaparaskeva airwayciliarecoverypostlungtransplantation AT philiprobinson airwayciliarecoverypostlungtransplantation
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Airway cilia recovery post lung transplantation

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