SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged as a pandemic. Paucity of information concerning the virus and therapeutic interventions have made SARS-CoV-2 infection a genuine threat to global public health. Therefore, there is a growing need for underst...

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Autores principales:	Md Zobaer Hasan, Syful Islam, Kenichi Matsumoto, Taro Kawai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a81831179b2b48a58cf0edd6bf8cccbf
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spelling	oai:doaj.org-article:a81831179b2b48a58cf0edd6bf8cccbf2021-12-02T18:51:47ZSARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs10.1038/s41598-021-96110-32045-2322https://doaj.org/article/a81831179b2b48a58cf0edd6bf8cccbf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96110-3https://doaj.org/toc/2045-2322Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged as a pandemic. Paucity of information concerning the virus and therapeutic interventions have made SARS-CoV-2 infection a genuine threat to global public health. Therefore, there is a growing need for understanding the molecular mechanism of SARS-CoV-2 infection at cellular level. To address this, we undertook a systems biology approach by analyzing publicly available RNA-seq datasets of SARS-CoV-2 infection of different cells and compared with other lung pathogenic infections. Our study identified several key genes and pathways uniquely associated with SARS-CoV-2 infection. Genes such as interleukin (IL)-6, CXCL8, CCL20, CXCL1 and CXCL3 were upregulated, which in particular regulate the cytokine storm and IL-17 signaling pathway. Of note, SARS-CoV-2 infection strongly activated IL-17 signaling pathway compared with other respiratory viruses. Additionally, this transcriptomic signature was also analyzed to predict potential drug repurposing and small molecule inhibitors. In conclusion, our comprehensive data analysis identifies key molecular pathways to reveal underlying pathological etiology and potential therapeutic targets in SARS-CoV-2 infection.Md Zobaer HasanSyful IslamKenichi MatsumotoTaro KawaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Md Zobaer Hasan Syful Islam Kenichi Matsumoto Taro Kawai SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
description	Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged as a pandemic. Paucity of information concerning the virus and therapeutic interventions have made SARS-CoV-2 infection a genuine threat to global public health. Therefore, there is a growing need for understanding the molecular mechanism of SARS-CoV-2 infection at cellular level. To address this, we undertook a systems biology approach by analyzing publicly available RNA-seq datasets of SARS-CoV-2 infection of different cells and compared with other lung pathogenic infections. Our study identified several key genes and pathways uniquely associated with SARS-CoV-2 infection. Genes such as interleukin (IL)-6, CXCL8, CCL20, CXCL1 and CXCL3 were upregulated, which in particular regulate the cytokine storm and IL-17 signaling pathway. Of note, SARS-CoV-2 infection strongly activated IL-17 signaling pathway compared with other respiratory viruses. Additionally, this transcriptomic signature was also analyzed to predict potential drug repurposing and small molecule inhibitors. In conclusion, our comprehensive data analysis identifies key molecular pathways to reveal underlying pathological etiology and potential therapeutic targets in SARS-CoV-2 infection.
format	article
author	Md Zobaer Hasan Syful Islam Kenichi Matsumoto Taro Kawai
author_facet	Md Zobaer Hasan Syful Islam Kenichi Matsumoto Taro Kawai
author_sort	Md Zobaer Hasan
title	SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
title_short	SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
title_full	SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
title_fullStr	SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
title_full_unstemmed	SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
title_sort	sars-cov-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a81831179b2b48a58cf0edd6bf8cccbf
work_keys_str_mv	AT mdzobaerhasan sarscov2infectioninitiatesinterleukin17enrichedtranscriptionalresponseindifferentcellsfrommultipleorgans AT syfulislam sarscov2infectioninitiatesinterleukin17enrichedtranscriptionalresponseindifferentcellsfrommultipleorgans AT kenichimatsumoto sarscov2infectioninitiatesinterleukin17enrichedtranscriptionalresponseindifferentcellsfrommultipleorgans AT tarokawai sarscov2infectioninitiatesinterleukin17enrichedtranscriptionalresponseindifferentcellsfrommultipleorgans
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SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

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